Hepatitis B screening before chemo deemed cost-effective

Hepatitis B screening before chemo deemed cost-Effective
Universal hepatitis B virus screening before chemotherapy for lymphoma reduces costs in most settings, according to a study published online June 18 in the Journal of Clinical Oncology.

(HealthDay) -- Universal hepatitis B virus (HBV) screening before chemotherapy for lymphoma reduces costs in most settings, according to a study published online June 18 in the Journal of Clinical Oncology.

Noting that potentially fatal HBV reactivation can be largely prevented with antiviral prophylaxis, Urszula Zurawska, M.D., from the University of Toronto, and colleagues developed a decision model to compare the clinical outcomes, costs, and cost-effectiveness of three HBV screening strategies for patients with lymphoma before plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy. The strategies were: screen all patients for surface antigen (HBsAg; Screen-All), screen patients at high-risk for HBV infection (Screen-HR), and screen no one (Screen-None). was administered to screened patients who tested positive until six months after completion of chemotherapy. Those not screened were given antiviral therapy only if HBV hepatitis occurred. Costs were given in Canadian dollars and a third-party payer perspective was adopted.

The researchers found that the dominant strategy was Screen-All, costing $32,589, compared with $32,598 for Screen-HR and $32,657 for Screen-None. Screen-All was also associated with the highest one-year survival rate (84.99 percent), compared with Screen-HR and Screen-None (84.96 and 84.86 percent, respectively). The prevalence of HBsAg positivity in the low-risk population influenced analysis; when this value was ≤0.20 percent the Screen-HR became the least costly.

"In patients receiving R-CHOP for lymphoma, screening all patients for HBV reduces the rate of HBV reactivation (10-fold) and is less costly than screening only high-risk patients or screening no patients," the authors write.

One author disclosed financial ties to Gilead Sciences.

More information: Abstract
Full Text

Related Stories

Recommended for you

Women's use of talc powder may be tied to ovarian cancer

date 13 hours ago

Deane Berg's doctor called her in the day after Christmas 2006 to give her the crushing news. She'd had her ovaries removed, the pathology results were back, and the information could not have been much worse. Berg had stage ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.