Personal history of prostate cancer linked to melanoma risk

Personal history of prostate cancer linked to melanoma risk

(HealthDay)—History of prostate cancer (PCa) is associated with an increased risk of melanoma, according to a study published online Nov. 4 in the Journal of Clinical Oncology.

Wen-Qing Li, Ph.D., from the National Institutes of Health in Rockville, Md., and colleagues conducted a prospective study to examine the correlation between PCa and the risk of using data from 42,372 participants in the Health Professionals' Follow-Up Study (HPFS). Pathology reports were used to confirm biennially self-reported PCa and melanoma. The association was confirmed in 18,603 participants from the Physicians' Health Study (PHS).

The researchers identified 529 melanomas in the HPFS. The risk of melanoma was significantly increased with personal history of PCa (multivariate adjusted hazard ratio, 1.83; 95 percent confidence interval, 1.32 to 2.54), while the risk of non-melanoma skin cancer was marginally increased with PCa (hazard ratio, 1.08; 95 percent confidence interval, 0.995 to 1.16). There was a significant difference in the magnitude of the association between melanoma and non-melanoma skin cancer. The risk of melanoma was not associated with of other cancers. In the PHS, the association between PCa and risk of incident melanoma was confirmed (hazard ratio, 2.17).

"Our finding of PCa diagnosis as a risk predictor for melanoma holds general public health significance, which may inform clinical practice to address the queries and aid the care of patients with PCa," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Retinol supplementation may lower melanoma risk

date Mar 05, 2012

(HealthDay) -- Retinol supplementation is associated with a lower risk of melanoma, according to research published online March 1 in the Journal of Investigative Dermatology.

Recommended for you

Therapy-resistant breast cancer mechanism revealed

date 14 hours ago

Mitsuyoshi Nakao, Director of the Institute of Molecular Embryology and Genetics in Kumamoto University and Associate Professor Noriko Saitoh revealed that a cluster of defined, non-coding RNAs are mechanistically involved ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.