Regulator of gene expression responsible for the progression of breast cancer

by Bill Hathaway
Gene regulator critical for breast cancer metastasis to the lung is identified
Credit: Shutterstock

Yale Cancer Center researchers have identified a regulator of gene expression that is responsible for the progression of breast cancer and its metastasis to the lung. The study appears online in Cell Reports.

In women, breast cancer is the most common cancer, and the second leading cause of cancer-related death. When it metastasizes, it does so primarily to the lung, brain, and bone. Only limited treatment options are available, and scientists are working to identify and test new drug targets for the development of effective therapies.

Recent studies suggest that abnormal gene expression contributes significantly to tumor formation and progression. But the regulators of such changes in metastasis are poorly understood.

The Yale researchers analyzed datasets of human breast tumors, as well as those of cancer cells, and found that overexpression of the enzyme RBP2 is critical for to the lung. Loss of RBP2, they also found, suppressed in mouse models.

The authors say their evidence suggests that RBP2 regulates a critical epigenetic switch that sets the stage for . They say the enzyme offers a novel target for development of therapies designed to inhibit and metastasis.

"Metastasis is the major cause of breast cancer-related death," said senior author Qin Yan, assistant professor of pathology at Yale School of Medicine. "Our study provides the first evidence, in genetically engineered mice, that a new class of enzymes could be targeted to suppress tumor metastasis."

add to favorites email to friend print save as pdf

Related Stories

New signaling pathway linked to breast cancer metastasis

Apr 02, 2012

Lymph nodes help to fight off infections by producing immune cells and filtering foreign materials from the body, such as bacteria or cancer cells. Thus, one of the first places that cancer cells are found when they leave ...

Recommended for you

Video: Is that double mastectomy really necessary?

Oct 24, 2014

When Angeline Vuong, 27,was diagnosed with cancer in one breast earlier this year, her first reaction was "A DOUBLE MASTECTOMY. NOW. " Turns out, she's far from alone: a recent JAMA study of 190,000 breast cancer cases in ...

User comments