Maternal insulin sensitivity linked to fetal brain activity

April 4, 2014
Maternal insulin sensitivity linked to fetal brain activity

(HealthDay)—Maternal insulin sensitivity is associated with fetal brain responses, according to a study published in the online March 25 in Diabetologia.

Katarzyna Linder, from the University Hospital Tübingen in Germany, and colleagues examined whether maternal metabolic changes during the oral glucose tolerance test influence activity in a study of 13 healthy pregnant women. Glucose and insulin measurements were taken at 0, 60, and 120 minutes to assess . Fetal auditory evoked fields were recorded at each time point and response latencies were determined.

The researchers observed an increase in mean maternal insulin from a fasting level of 67 ± 25 to 918 ± 492 pmol/l at 60 minutes after ingestion of glucose. Glucose levels increased from 4.4 ± 0.3 to 7.4 ± 1.1 mmol/l. Fetal response latencies decreased over the same period, from 297 ± 99 to 235 ± 84 ms (P = 0.01), and were stable until 120 minutes (251 ± 91 ms; P = 0.39). Sixty minutes after ingestion, a negative correlation was seen between maternal insulin sensitivity and fetal response latencies (P = 0.02). On categorization of the group according to maternal insulin sensitivity, a slower response to auditory stimuli was seen for fetuses of insulin-resistant mothers (283 ± 79 ms) compared with insulin-sensitive mothers (178 ± 46 ms; P = 0.03).

"These findings provide the first evidence of a direct effect of maternal metabolism on fetal brain activity and suggest that central may be programmed during ," the authors write.

Explore further: Maternal glycemic status linked to epigenetic changes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Sucralose affects response to oral glucose load in obese

July 2, 2013

(HealthDay)—For obese adults who do not use non-nutritive sweetener (NNS), sucralose affects the glycemic and insulin responses to an oral glucose load, according to a study published online April 30 in Diabetes Care.

Artificial sweeteners produce no glucagon response

January 14, 2014

(HealthDay)—Artificial sweeteners do not produce any changes in glucose metabolism compared to a glass of water, according to a letter published in the December issue of Diabetes Care.

Model predicts blood glucose levels 30 minutes later

March 25, 2014

A mathematical model created by Penn State researchers can predict with more than 90 percent accuracy the blood glucose levels of individuals with type 1 diabetes up to 30 minutes in advance of imminent changes in their levels—plenty ...

Recommended for you

Gut bacteria imbalance increases diabetes risk

July 13, 2016

Currently, scientists think the major contributors to insulin resistance are excess weight and physical inactivity, yet ground-breaking new research by an EU funded European-Chinese team of investigators called MetaHit have ...

Which diabetes drug is best?

July 19, 2016

(HealthDay)—No single drug to treat type 2 diabetes stands out from the pack when it comes to reducing the risks of heart disease, stroke or premature death, a new research review finds.

Team explores genetic architecture of type 2 diabetes

July 11, 2016

New research from a large international team of scientists offers a more complete picture of the genes responsible for type 2 diabetes, demonstrating that previously identified common alleles shared by many in the world are ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.