Cancer

Loss of cilia leads to melanoma

Most cells in the human body have a cilium, a slender cell protuberance that picks up signals from the cell's external environment. Researchers at the University of Zurich have now shown that these fine sensory antennae play ...

Cancer

Melanoma cells rewire to resist drug treatment

In 2014, new combination therapies to treat patients with metastatic melanoma hit the market, helping extend the lives of those with this aggressive disease. Yet unfortunately, after several months of treatment, almost all ...

Cancer

A protein that defines the melanoma blueprint

The main goals of the Melanoma Group at the Spanish National Cancer Research Centre (CNIO) are to identify biomarkers of tumour progression and to validate novel therapeutic targets in melanoma. In particular, their research ...

Cancer

Scientists identify weak point in deadly eye melanoma

A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma ...

Cancer

Scientists pinpoint surprising origin of melanoma

Led by Jean-Christophe Marine (VIB-KU Leuven), a team of researchers has tracked down the cellular origin of cutaneous melanoma, the deadliest form of skin cancer. The team was surprised to observe that these very aggressive ...

Cancer

New combination treatment flips the switch on melanoma cells

Think of the protein BH3 like a finger that turns off a cancer cell survival switch. The problem is that most cancer cells have found ways to remove this "finger—commonly, by breaking the action of a gene called p53 that ...

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