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Genetics news
Genetics
Gene 'reversal' in fruit flies points to new hope for Alzheimer's treatment
A study published in The American Journal of Human Genetics by researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital provides solutions ...
17 hours ago
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Oncology & Cancer
Human and HPV genes combine to form extrachromosomal DNA that promotes oropharyngeal tumor growth, study reveals
The incidence of Human Papillomavirus (HPV)–associated oropharyngeal cancers—tumors of the back of the mouth and throat—is rising. If caught early, most of these cancers have a high survival rate, but about 20% of patients ...
20 hours ago
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Alpha-1 antitrypsin deficiency: Study reveals why some patients with the hereditary disease remain healthy
Alpha-1-antitrypsin is a so-called protease inhibitor, a type of enzyme inhibitor. It is produced in the liver but exerts its effects in the lungs, where it regulates immune cell activity. This regulation is crucial, and ...
19 hours ago
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Genetic variant reveals how cleft lip and cleft palate can arise
Cleft lip and cleft palate are among the most common birth defects, occurring in about one in 1,050 births in the United States. These defects, which appear when the tissues that form the lip or the roof of the mouth do not ...
22 hours ago
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Algorithm pinpoints potential disease-causing variants in non-coding regions of human genome
Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn Medicine) have successfully employed an algorithm to identify potential mutations which ...
22 hours ago
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A common diabetes drug may prevent leukemia, mouse study suggests
Metformin, a widely used and affordable diabetes drug, could prevent a form of acute myeloid leukemia in people at high risk of the disease, a study in mice has suggested. Further research in clinical trials will be needed ...
23 hours ago
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Mouse model reveals how the Icelandic mutation protects against Alzheimer's disease
RIKEN researchers have demonstrated the protective effects of a specific genetic mutation against Alzheimer's disease in animals for the first time. This could eventually lead to the development of new ways to treat the neurodegenerative ...
Apr 17, 2025
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Supercharged mitochondria spark aging-related blood disorders
As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations. These mutations can give the cells a growth advantage, laying the foundation for developing serious health ...
Apr 16, 2025
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Reprogramming cancer cells to treat an aggressive type of leukemia
A Ludwig Cancer Research study has identified a novel strategy for treating acute myelogenous leukemia (AML), an aggressive blood cancer for which the median survival time following diagnosis remains just 8.5 months.
Apr 16, 2025
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Discovery of FOXR2 activation in various brain tumors refines diagnosis to improve care
Physicians classify brain tumors and determine treatment options, in part, by the genes they express. According to World Health Organization standards, the abnormal activation of oncogene FOXR2 only occurs in central nervous ...
Apr 16, 2025
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True number of people living with Huntington's disease gene in Northern Scotland determined
The number of people who have the gene that causes Huntington's disease in Northern Scotland has been accurately counted for the first time in 35 years in new research from the University of Aberdeen in partnership with NHS ...
Apr 16, 2025
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Key to the high aggressiveness of pancreatic cancer identified
Pancreatic cancer is one of the most aggressive cancers and has one of the lowest survival rates—only 10% after five years. One of the factors contributing to its aggressiveness is its tumor microenvironment, known as the ...
Apr 15, 2025
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Common genetic variants linked to drug-resistant epilepsy
Certain common genetic changes might make some people with focal epilepsy less responsive to seizure medications, finds a new global study led by researchers at UCL and UTHealth Houston.
Apr 15, 2025
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Gene-based blood test for melanoma may catch early signs of cancer's return
Monitoring blood levels of DNA fragments shed by dying tumor cells may accurately predict skin cancer recurrence, a new study shows.
Apr 15, 2025
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Analysis identifies gene mutations that may drive carcinogenesis in colorectal tumors
Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide. The mutational landscape of CRC is well-characterized, revealing key ...
Apr 15, 2025
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Single-cell profiling methods compared for gut biopsy analysis
Research on gastrointestinal diseases, especially cancer, has mainly focused on epithelial cells, which line the surfaces of organs, are important for various functions, and are believed to be the cells that go awry to cause ...
Apr 15, 2025
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Gene identified that blocks healing after spinal cord injury
An estimated 18,000 people in the United States annually suffer from new injuries to their spinal cords. Unfortunately for those afflicted, no FDA-approved therapy is currently available. Scientists at UC San Diego are looking ...
Apr 14, 2025
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A cell atlas to uncover significant shifts in the neuroblastoma tumor microenvironment
Researchers at Children's Hospital of Philadelphia (CHOP) developed a longitudinal atlas of neuroblastoma, a common and potentially deadly childhood cancer, to gain a deeper understanding into precise molecular mechanisms ...
Apr 14, 2025
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Drug trio sparks hope for families affected by inherited motor neuron disease
A team of researchers from the University of Wollongong (UOW) have discovered that a unique trio of medications could hold the key to improved treatment outcomes for hereditary cases of motor neuron disease (MND) caused by ...
Apr 14, 2025
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How inherited genes help shape the course of cancer
A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and colleagues around the world, has discovered that the ...
Apr 14, 2025
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Scalable technique for single-cell sequencing enhances drug screening research
A study by scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) introduces a more cost-effective, scalable single-cell sequencing technique for co-sequencing RNA and DNA. The tool, called DEFND-seq (DNA and ...
Apr 14, 2025
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Optical genome mapping technology shows promise for diagnosis, prognosis and therapeutic options of multiple myeloma
Researchers have demonstrated the potential of the innovative optical genome mapping (OGM) technique for the diagnosis, prognosis, and therapeutic management of multiple myeloma. This new study in The Journal of Molecular ...
Apr 14, 2025
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Complete genome sequences of six ape species unveiled
Differences among the DNA of seven ape species—including humans—are greater than originally thought, according to an international team led by researchers at Penn State, the National Human Genome Research Institute (NHGRI) ...
Apr 12, 2025
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Sex differences in carotid artery plaques and stroke symptoms revealed in new study
A new study published in Nature Cardiovascular Research found that while carotid artery narrowing can lead to stroke in both men and women, the symptoms and plaque characteristics often differ between the sexes. Even though ...
Apr 11, 2025
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Key genes in Parkinson's disease discovered using CRISPR technology
A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also carry such variants do not. ...
Apr 11, 2025
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