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Genetics news
Genetics
Researchers suggest motor delay and low muscle tone may indicate genetic disorders
In a new study, UCLA Health researchers have found that motor delay and low muscle tone were common signs of an underlying genetic diagnosis in children with neurodevelopment disorders.
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Genetics
New study identifies genetic changes in brain development that may contribute to schizophrenia
A collaborative study between researchers at the Icahn School of Medicine at Mount Sinai and Harvard Medical School has identified genetic mutations that occur during brain development and may contribute to the development ...
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Researchers clarify role of VGLL3 in DNA double-strand break repair and chemotherapy
A research group led by Prof. Guo Caixia from the Beijing Institute of Genomics of the Chinese Academy of Sciences (CAS) and Tang Tie-Shan from the Institute of Zoology of CAS have discovered that VGLL3 modulates chemosensitivity ...
2 hours ago
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New study challenges longstanding assumption about the cause of the genome's most common mutation
A Ludwig Cancer Research study has punctured a longstanding assumption about the source of the most common type of DNA mutation seen in the genome—one that contributes to many genetic diseases, including cancer.
22 hours ago
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Large-scale study identifies prostate cancer genetic risk factors in a diverse group of African men
Researchers have identified the genetic risk factors that contribute to prostate cancer in a diverse group of African men. Although research and treatment are scant, this first large-scale African genomics study could signal ...
23 hours ago
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How your skin tone could affect how well your medication works
Skin pigmentation may act as a "sponge" for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report in a perspective article published in the journal ...
20 hours ago
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New structural variant detection tool could significantly advance genomic analysis and precision medicine
A team of Vanderbilt researchers has developed a novel tool in the detection and analysis of structural variants (SVs) in human genomes that could potentially transform genomic analysis and precision medicine. The research ...
20 hours ago
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Combination therapy may improve treatment response in pancreatic cancer
Northwestern Medicine investigators have discovered that a novel combination therapy promotes cancer cell death and tumor regression in mouse models of pancreatic cancer, according to a recent study published in the journal ...
23 hours ago
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Inducing a gene that informs cell signaling could halt diabetic kidney disease, study shows
New research by Stony Brook Medicine nephrology specialists that centers on targeting key cellular signaling between two types of kidney cells, and inducing a certain gene within those processes, may help prevent or reduce ...
Oct 10, 2024
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Stem cell discovery highlights importance of DNA methylation in cancer
A study led by Umeå University, Sweden, presents new insights into how stem cells develop and transition into specialized cells. The discovery can provide increased understanding of how cells divide and grow uncontrollably ...
Oct 10, 2024
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An integral T cell pathway has implications for understanding sex-based immune response
The well-established existence of sex differences in immune responses, including immune responses driven by T cells, cuts both ways. Females tend to have a stronger immune response to pathogens, yet most patients who have ...
Oct 10, 2024
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Scientists create first map of DNA modification in the developing human brain
A UCLA-led study has provided an unprecedented look at how gene regulation evolves during human brain development, showing how the 3D structure of chromatin—DNA and proteins—plays a critical role. This work offers new ...
Oct 9, 2024
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Novel gene therapy shows promise in targeting a mutation linked to epilepsy
Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) are working on a therapy that holds potential in treating patients with epilepsy, a neurological disorder defined by recurring ...
Oct 9, 2024
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Study uncovers mutations and DNA structures driving bladder cancer
How bladder cancer originates and progresses has been illuminated as never before in a study led by researchers at Weill Cornell Medicine and the New York Genome Center. The researchers found that antiviral enzymes that mutate ...
Oct 9, 2024
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Newly discovered genetic marker could pave the way for future Alzheimer's disease therapeutics
Indiana University School of Medicine researchers have identified a new genetic marker that could play a role in the development of Alzheimer's disease, which is characterized by two primary pathologies: amyloid-beta plaques ...
Oct 9, 2024
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Study finds new genetic loci associated with dementia
A research team comprising several researchers within the University of Kentucky's Sanders-Brown Center on Aging has investigated the genetic risk of neuropathological traits commonly seen by neuropathologists performing ...
Oct 9, 2024
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The secret to slimming? Special 'skinny genes' double weight loss
The secret to losing weight could all be down to a combination of 14 "skinny genes," a new study has found.
Oct 9, 2024
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Genetic analysis of 25,000 Chinese mothers and infants reveals unique genes associated with disease risk
Genome-wide association studies have great potential for advancing our understanding of the genetic background of diseases, but so far, few association studies have focused on maternal and newborn diseases, and most have ...
Oct 9, 2024
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Study: DOCK8 mutation disrupts helper T cell differentiation via glycolytic pathway regulation
A study, published in the journal MedComm and led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the dedicator of cytokinesis 8 (DOCK8) gene in the differentiation of helper ...
Oct 9, 2024
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DAPK3 emerges as a new regulator of migration of triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is the subtype of breast cancer that is the hardest to treat. TNBC patients account for more than 20,000 cases of this condition annually in the U.S. alone. They experience worse outcomes ...
Oct 8, 2024
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New technique that makes competition between tumor cells visible can help personalize treatments for multiple myeloma
Not all cells within the same cancer are the same. They all have genetic errors that turn them into tumor cells, but these errors are not identical. In each cancer, there are populations of cells with different mutations, ...
Oct 8, 2024
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How diabetes risk genes make cells less resilient to stress
The cells in your pancreas, like people, can only handle so much stress before they start to break down. Certain stressors, such as inflammation and high blood sugar, contribute to the development of type 2 diabetes by overwhelming ...
Oct 8, 2024
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Cell line models identify cause of melanoma with drug resistance
Melanoma is a type of cancer that originates from melanocytes, the cells responsible for producing skin pigment, and is known as the most lethal form of skin cancer due to its high rates of metastasis and recurrence. With ...
Oct 8, 2024
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Nobel scientist uncovered tiny genetic switches with big potential
Harvard geneticist Gary Ruvkun vividly remembers the late-night phone call with his longtime friend and now 2024 Nobel Prize in Medicine co-laureate Victor Ambros, when they made their groundbreaking discovery of genetic ...
Oct 8, 2024
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How epigenetic modifications can influence the onset and progression of various diseases
Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment. A review article titled ...
Oct 8, 2024
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