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Clinical pharmacology news
Mirror fragments intercept Alzheimer's-causing protein
Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small mirror protein that disables a causal factor of Alzheimer's disease, amyloid-beta.
16 hours ago
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Nursing home flu outbreaks—statistical approach reveals keys to preventing hospitalizations
In nursing homes, influenza spreads quickly. Even in facilities with separate wings, staff move throughout the home, caring for medically complex older adults who often share rooms. In this way, a single case of influenza ...
9 hours ago
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Common antidepressant may ease long COVID fatigue
A randomized clinical trial found that the antidepressant fluvoxamine significantly reduces long COVID-related fatigue, one of the condition's most persistent and debilitating symptoms, while the diabetes drug metformin showed ...
12 hours ago
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New discovery could slow Parkinson's disease and reduce life-threatening lung injury
Scientists at Florida International University have developed a promising new compound that could slow the progression of Parkinson's disease and protect against life-threatening lung injury by targeting a key process inside ...
13 hours ago
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Common antidepressant eases fatigue associated with long COVID, study finds
A global research team co‑led by McMaster University has identified one of the first medications shown to meaningfully reduce fatigue in people living with long COVID—a breakthrough for millions still struggling with persistent ...
19 hours ago
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Sotatercept shows promise for a type of pulmonary hypertension linked to heart failure with preserved EF
Patients who have heart failure with preserved ejection fraction (HFpEF) and high blood pressure in the lungs (pulmonary hypertension) experienced significant improvements in blood pressure and vascular health after taking ...
19 hours ago
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Investigational drug delivers mixed results for uncontrolled blood pressure
The investigational drug tonlamarsen—which is designed to lower blood pressure by reducing the production of angiotensinogen, a protein that turns into the hormone that regulates blood pressure—caused a significant and sustained ...
Mar 31, 2026
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Organ-on-a-chip technology replicates decades of human aging in just four days
Over one billion people worldwide are over 60, and the population is projected to more than double by 2050. But as more people live into their 60s, 70s, and 80s, health care systems across the globe may face new challenges ...
Mar 30, 2026
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New compound MF-8 may treat anxiety and memory loss with fewer side effects
Scientists at City University of Hong Kong (CityUHK) have made progress in recent months with the discovery of a novel compound, named MF-8. The compound and its associated pharmaceuticals demonstrate significant potential ...
Mar 30, 2026
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Placing battery tech directly on tissue to deliver lithium ions for targeted pain relief
A new study from the University of Chicago taps an ingredient most often used in the lithium-ion batteries that power our devices to open new avenues in biomedical technology. Lithium plays vital roles in the body, but taking ...
Mar 30, 2026
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Brain wiring model could shorten path to new medicines
A new, more life-like physical model of microscopic nerve fibers called axons could speed up the discovery of medicines for multiple sclerosis and other degenerative brain diseases, suggests a new study led by UCL researchers. ...
Mar 30, 2026
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20,000 lab-grown human retinas reveal how cone photoreceptor cells resist degeneration
Scientists led by Botond Roska at the Institute of Molecular and Clinical Ophthalmology Basel (IOB) and collaborators have identified genetic pathways and compounds capable of protecting cone photoreceptors from the degeneration ...
Mar 30, 2026
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Switching to integrase inhibitors from protease inhibitors is associated with new diabetes risk in people with HIV
Diabetes mellitus affects more than 10% of people with HIV, and its incidence is rising as the population ages, according to the National Institutes of Health. Antiretroviral therapies that treat HIV by blocking specific ...
Mar 30, 2026
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uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice
Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two main reasons: Tumor ...
Mar 30, 2026
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Mavacamten improves obstruction in adolescents with hypertrophic cardiomyopathy
Adolescent patients with obstructive hypertrophic cardiomyopathy (HCM) who received the drug mavacamten saw a significant improvement in left ventricular outflow tract (LVOT) gradient, a measure of blood flow obstruction ...
Mar 30, 2026
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New analytical method reveals how drug combinations act in leukemia
Acute myeloid leukemia (AML) remains one of the most difficult blood cancers to treat. Although drug combinations are often more effective than single agents, their true mechanisms of action have been poorly understood. A ...
Mar 30, 2026
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Blocking NOX-1 enzyme may extend ketamine's antidepressant effects
Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers rapid relief, its antidepressant effects fade within a few weeks. Now, researchers from Japan have ...
Mar 30, 2026
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Q&A: Should you trust trending peptide injections?
If you could inject yourself with a substance that purports to make you tanner, fitter, and healthier, would you? Many people are saying "yes." Online, social media influencers tout vials of substances with names like BPC-157 ...
Mar 30, 2026
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Triglyceride-lowering drug does not affect plaque in arteries at one year in patients with elevated triglycerides: Study
Despite experiencing significant reductions in triglycerides, patients with triglycerides over 150 mg/dL and a high risk of atherosclerosis did not experience any significant change in the amount of non-calcified plaque in ...
Mar 30, 2026
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Can I drive when taking medicinal cannabis? Is it safe?
Your doctor has just prescribed medicinal cannabis. You think it's helping. But you rely on your car to get to work and pick up the kids.
Mar 30, 2026
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FDA weighs expanding what can go into supplements
What's in your supplements could soon change.
Mar 30, 2026
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Switching from dulaglutide to tirzepatide boosts patient-reported well-being for people with type 2 diabetes: Analysis
An analysis of patient-reported outcomes (PROs) from the SURPASS-SWITCH trial found that adults with type 2 diabetes who switched from dulaglutide to tirzepatide not only saw stronger improvements in blood sugar and weight ...
Mar 30, 2026
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Researchers compare brain markers affected by brief versus lengthy exposure to alcohol in mice
Erica Periandri and Gabor Egervari, from Washington University in St. Louis, led a study to explore how alcohol exposure in male mice influences gene expression and mechanisms that regulate gene function—or epigenetics.
Mar 30, 2026
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FDA warns biotech firm over cancer drug claims
The U.S. Food and Drug Administration (FDA) has warned a biotech company about claims that its bladder cancer drug could treat and prevent multiple types of cancer.
Mar 29, 2026
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Solving the oxygen problem in cell-based drug delivery
Implanting living cells as long-term drug producers could transform treatment for numerous diseases, but it is difficult to house the tiny workers in quantities high enough to ensure dosage needs are met while also keeping ...
Mar 28, 2026
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