Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma
A new research perspective titled "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma" has been published in Oncotarget.
Feb 7, 2024
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Amino Acids, Peptides, and Proteins: News and Research on Proto-Oncogene Proteins
MeSH tree: D12.776.624.664.700
Q&A: Behind the approvals—decades of research lead to a new generation of targeted cancer therapies
Last month, the U.S. Food and Drug Administration (FDA) approved the use of the drug capivasertib, in combination with a current cancer treatment called fulvestrant for patients with the most common type of breast cancer, ...
Dec 21, 2023
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Key signaling protein identified as possible target for new therapies in hard-to-treat cancers
The unique signaling protein known as TRPM7 can stimulate and interact with an important cellular signaling hub called the AKT machinery, which is a well-known component of multiple cellular functions that drive growth and ...
Oct 26, 2023
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Veratramine found to inhibit androgen-independent prostate cancer
The DGIST Core Protein Resources Center and Honam National Institute of Biological Resources announced that they have molecularly elucidated the mechanism by which veratramine, extracted from the wild island plant Veratrum ...
Sep 15, 2023
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A novel strategy to suppress triple negative breast cancer growth
In 2022, a team of researchers at Baylor College of Medicine discovered that a little-known enzyme called MAPK4 is involved in the growth of triple negative breast cancer (TNBC) and its resistance to certain therapies. Looking ...
Aug 2, 2023
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Testing for 'zombie' cells could boost number of hearts for transplant
Testing older potential organ donors for dangerous "zombie" cells could help to increase the number of hearts available for transplant, according to research presented at the British Cardiovascular Society conference in Manchester.
Jun 5, 2023
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Researchers image live drug response and resistant 'pockets' in pancreatic cancer
Pancreatic cancer drug response and resistance has been uncovered in unprecedented detail, thanks to a research tool developed at the Garvan Institute.
Apr 28, 2023
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Team successfully generates mouse models for two subtypes of multiple myeloma
B lymphocytes—also known simply as B cells—play a central role in the immune system. If pathogens enter the body, B cells are activated and develop into plasma cells, which then release antibodies. One important step in this ...
Mar 16, 2023
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Actinidia arguta (sarunashi) juice found to inhibit lung cancer in mice
Lung cancer is a leading cause of death in Japan and across the globe. Among all the cancers, lung cancer has one of the lowest five-year survival rates. Smoking tobacco and using tobacco-based products is known to heavily ...
Dec 28, 2022
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Poor gut health may drive multiple sclerosis—better diet may ease it
Researchers from Rutgers Robert Wood Johnson Medical School's Department of Neurology have traced a previously observed link between microscopic organisms in the digestive tract—collectively known as the gut microbiome—and ...
Dec 15, 2022
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