Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma
A new research perspective titled "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma" has been published in Oncotarget.
Feb 7, 2024
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Enzymes and Coenzymes: News and Research on Phosphotransferases (Alcohol Group Acceptor)
MeSH tree: D08.811.913.696.620
New method improves detection of potential therapeutic tumor targets in human biopsies
Many cancers, including some types of breast cancer, are driven by alterations in the activity of cellular enzymes called kinases. Therapies that directly inhibit these cancer-promoting activities have proven to be effective ...
Jan 16, 2024
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Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells
Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death worldwide. It is marked by lung damage that is lasting and incurable, leaving lung transplantation as the only viable treatment option. Unfortunately, ...
Jan 5, 2024
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Q&A: Behind the approvals—decades of research lead to a new generation of targeted cancer therapies
Last month, the U.S. Food and Drug Administration (FDA) approved the use of the drug capivasertib, in combination with a current cancer treatment called fulvestrant for patients with the most common type of breast cancer, ...
Dec 21, 2023
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Organoids study discovers promising treatment for deadly uterine cancer
QUT scientists have discovered a promising new therapy for a deadly type of endometrial cancer that has a poor prognosis if the cancer spreads or returns after initial treatment, a plight that affects 15%–20% of endometrial ...
Dec 13, 2023
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New cause of diabetes discovered, offering potential target for new classes of drugs to treat the disease
Researchers at Case Western Reserve University and University Hospitals have identified an enzyme that blocks insulin produced in the body—a discovery that could provide a new target to treat diabetes.
Dec 8, 2023
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Spanish scientists discover a promising therapeutic target for cardiac arrhythmias
A study led by Guadalupe Sabio and José Jalife at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid has identified a new signaling mechanism implicated in the development of ventricular fibrillation, ...
Nov 27, 2023
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Boosting beta cells to treat type 2 diabetes
Researchers at Weill Cornell Medicine have uncovered a novel route to stimulate the growth of healthy insulin-producing pancreatic beta cells in a preclinical model of diabetes. The findings hold promise for future therapeutics ...
Nov 8, 2023
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The first oncogene was found more than 40 years ago: Research discovers it has a previously unknown mechanism of action
In the late 1970s, the relationship between the c-Src gene and cancer was discovered. The first oncogene was identified. Since then, c-Src has been found to be overactivated in half of colon, liver, lung, breast, prostate ...
Oct 31, 2023
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Study directly links high insulin levels to pancreatic cancer
A new study from researchers at the University of British Columbia's Faculty of Medicine reveals a direct link between high insulin levels, common among patients with obesity and type 2 diabetes, and pancreatic cancer.
Oct 31, 2023
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