New antibiotic compound enters phase I clinical trial

November 9, 2011, Wellcome Trust
New antibiotic compound enters phase I clinical trial
False colour light micrograph of Clostridium difficile. Credit: Derren Ready, Wellcome Images.

(Medical Xpress) -- Novacta Biosystems has commenced dosing of the first healthy volunteers in a phase I clinical trial of a new antibiotic to treat the hospital superbug Clostridium difficile.

Laboratory studies have shown that the new compound, NVB302, is effective against all strains of difficile tested, without adversely affecting the healthy bacteria that are normally found in the gut.

Developed with support from a Wellcome Trust Strategic Translation Award, NVB302 is now being tested in a first-in-man trial to determine the safety and tolerability of the compound in healthy volunteers.

C. difficile is a hospital-acquired infection that causes severe and can be life threatening, particularly for the elderly. Few currently available are effective against C. difficile infection and is a growing threat.

Ted Bianco, Director of Technology Transfer at the Wellcome Trust, said: "C. difficile is a particularly insidious infection that catches people at their most vulnerable. With the ever-present threat of increasing drug resistance, taking this new antibiotic into is a significant step on the road to replenishing our depleted medicine cabinet."

NVB302 is a member of a class of antibiotics known as the type B lantibiotics, a naturally occurring class of antibiotic compounds found in many bacteria. Lantibiotics have shown great potential to treat superbug infections such as C. difficile and MRSA; however, conventional has not been able to optimise the structure of the naturally occurring compounds into a form with the potential to treat human disease.

Novacta's proprietary technologies have allowed the structural manipulation and optimisation of the lantibiotics' , to unlock the potential of this novel and underexploited class of compounds.

"We are very pleased to announce the initiation of clinical studies with NVB302," said Dr Mike Dawson, Chief Scientific Officer of Novacta. "This is a major milestone for the company."

Dr Richard Garraway, a Partner in CPHA and member of the Novacta Board of Directors, added: "Celtic is delighted that Novacta has achieved this significant milestone. We are committed to supporting the company through this clinical programme and to work with Novacta in securing an attractive partner for the late-stage clinical development and commercialisation of NVB302."

Explore further: Hope for powerful new C diff. treatment

Related Stories

Hope for powerful new C diff. treatment

September 19, 2011
MGB Biopharma, a biopharmaceutical company which has licensed technology from the University of Strathclyde in Glasgow, Scotland, is developing a powerful new antibiotic treatment for resistant infections including the deadly ...

Hospital superbug debugged

October 13, 2011
An international team of scientists led by Monash University researchers has uncovered how a common hospital bacterium becomes a deadly superbug that kills increasing numbers of hospital patients worldwide and accounts for ...

Recommended for you

Opioid addiction treatment behind bars reduced post-incarceration overdose deaths in RI

February 14, 2018
A treatment program for opioid addiction launched by the Rhode Island Department of Corrections was associated with a significant drop in post-incarceration drug overdose deaths and contributed to an overall drop in overdose ...

Heroin vaccine blocks lethal overdose

February 14, 2018
Scientists at The Scripps Research Institute (TSRI) have achieved a major milestone toward designing a safe and effective vaccine to both treat heroin addiction and block lethal overdose of the drug. Their research, published ...

Study shows NIH spent >$100 billion on basic science for new medicines

February 12, 2018
Federally funded research contributed to the science underlying all new medicines approved by the FDA over the past six years, according to a new study by Bentley University.

Opioid use increases risk of serious infections

February 12, 2018
Opioid users have a significantly increased risk of infections severe enough to require treatment at the hospital, such as pneumonia and meningitis, as compared to people who don't use opioids.

Placebo pills prescribed honestly help cancer survivors manage symptoms

February 9, 2018
Long after cancer treatment ends, many continue to deal with one particular symptom that refuses to go away: fatigue. In a new study, researchers at the University of Alabama at Birmingham and Harvard Medical School have ...

Multinational companies continue to produce unregulated antibiotics in India

February 5, 2018
Millions of unapproved antibiotics are being sold in India, according to a new study by researchers at Queen Mary University of London and Newcastle University.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.