Caloric restriction restores glucose response in diabetes

August 9, 2012
Caloric restriction restores glucose response in diabetes
Neuronal responsiveness of the hypothalamus to glucose, critical in the regulation of feeding, can be restored in patients with type 2 diabetes by short-term caloric restriction, according to a study published online July 30 in Diabetes.

(HealthDay) -- Neuronal responsiveness of the hypothalamus to glucose, critical in the regulation of feeding, can be restored in patients with type 2 diabetes by short-term caloric restriction, according to a study published online July 30 in Diabetes.

Wouter M. Teeuwisse, from the Leiden University Medical Center in the Netherlands, and colleagues performed on 10 male patients with type 2 diabetes, before and after four days of a very . Neuronal activity in the hypothalamus in response to an oral glucose load was measured.

Before caloric restriction, the researchers found that glucose intake had no effect on the hypothalamus (no signal decrease), noting that glucose ingestion normally inhibits hypothalamic neuronal activity. After caloric restriction there was a prolonged signal decrease following glucose ingestion.

"The results of the current study demonstrate that short-term readily normalizes hypothalamic responsiveness to glucose ingestion in patients with type 2 diabetes," Teeuwisse and colleagues conclude.

Explore further: Diet soda linked to increase in glucagon-like peptide 1 levels

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Diet soda linked to increase in glucagon-like peptide 1 levels

March 22, 2012
(HealthDay) -- Drinking a diet soda before a glucose load is associated with increased glucagon-like peptide 1 (GLP-1) secretion in individuals with type 1 diabetes and healthy controls, but not in those with type 2 diabetes, ...

Restricted calorie diet improves heart function in obese patients with diabetes

November 28, 2011
A low-calorie diet eliminates insulin dependence and leads to improved heart function in obese patients with type 2 diabetes, according to a study presented today at the annual meeting of the Radiological Society of North ...

Treating obesity via brain glucose sensing

July 26, 2011
The past two decades have witnessed an epidemic spread of obesity-related diseases in Western countries. Elucidating the biological mechanism that links overnutrition to obesity could prove crucial in reducing obesity levels. ...

Research reveals hormone action that could lead to treatments for type 2 diabetes

September 30, 2011
(Medical Xpress) -- Researchers at the University of Cincinnati have discovered that the immediate improvement in blood sugar (blood glucose) for those with type 2 diabetes who undergo gastric bypass surgery is related to ...

Scientists find missing link in regulation of glucose

December 22, 2011
(Medical Xpress) -- A team led by USC neuroscientist Alan Watts identified for the first time a biochemical signal that helps regulate the amount of glucose in the blood.

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.