ACR: Strontium ranelate cuts progression of knee OA

November 12, 2012
ACR: strontium ranelate cuts progression of knee OA
The osteoporosis therapeutic strontium ranelate reduces radiographic and radiological progression of knee osteoarthritis, according to a study presented at the annual meeting of the American College of Rheumatology, held from Nov. 10 to 14 in Washington, D.C.

(HealthDay)—The osteoporosis therapeutic strontium ranelate (SrRan) reduces radiographic and radiological progression of knee osteoarthritis, according to a study presented at the annual meeting of the American College of Rheumatology, held from Nov. 10 to 14 in Washington, D.C.

Jean-Yves Reginster, M.D., Ph.D., from the University of Liège in Belgium, and colleagues conduced a double-blind, placebo-controlled three-year study involving 1,371 patients (63 ± 7 years; 69 percent female) with symptomatic primary knee OA (Kellgren and Lawrence grade 2 or 3, joint space width [JSW] 3.5 ± 0.8 mm) who were randomized to receive SrRan (1 or 2 g/day) or placebo.

The researchers found that SrRan correlated with less progression of cartilage degradation and a significantly smaller decrease in JSW (−0.23 ± 0.56 mm with 1 g/day; −0.27 ± 0.63 mm with 2 g/day; and −0.37 ± 0.59 mm with placebo), with no difference between doses. SrRan at both doses also correlated with significantly less radiological and radioclinical progression. SrRan at the 2 g/day dose led to significant reductions in total Western Ontario and McMaster Universities Osteoarthritis Index score, including the pain and physical function subscores and . SrRan was well tolerated, with 17 percent of the patients in each group reporting a serious emergent adverse effect.

"Results of the present trial show also [SrRan's] ability to reduce the progression of osteoarthritis," Reginster said in a statement. "This could be a major step in the global management of musculo-skeletal disorders in the ."

Several authors disclosed to pharmaceutical companies, including Servier Laboratories, the manufacturer of strontium ranelate.

Explore further: BMI, post-exercise knee laxity change tied to OA progression

More information: Abstract
More Information

Related Stories

BMI, post-exercise knee laxity change tied to OA progression

August 21, 2012
(HealthDay) -- In patients with osteoarthritis (OA) of the knee, changes in knee joint laxity during stair climbing or other repetitive physical activity and baseline body mass index (BMI) are associated with disease progression, ...

Study looks at pain processing abnormalities in knee OA

September 17, 2012
(HealthDay)—For patients with knee osteoarthritis (K-OA), the lack of correlation between clinical pain and radiographic evidence of disease severity may be due to central sensitization, according to a study published online ...

Walking speed is a marker for knee osteoarthritis

March 20, 2012
(HealthDay) -- Slower walking speed may be a marker for identifying those at risk for knee osteoarthritis (OA), according to a study published online March 5 in Arthritis Care & Research.

Study indicates nanoparticles could help pain-relieving osteoarthritis drugs last longer

October 26, 2011
A novel study demonstrates that using nanoparticles to deliver osteoarthritis drugs to the knee joint could help increase the retention of the drug in the knee cavity, and therefore reduce the frequency of injections patients ...

Donepezil found helpful in dementia with lewy bodies

July 31, 2012
(HealthDay) -- For patients with dementia with Lewy bodies (DLB), treatment with 5 or 10 mg/day donepezil is associated with significant cognitive, behavioral, and global function improvements, according to research published ...

Recommended for you

Osteoarthritis could be treated as two diseases, scientists reveal

January 10, 2018
Scientists at The University of Manchester have discovered that most people with osteoarthritis can be subdivided into two distinct disease groups, with implications for diagnosis and drug development.

US arthritis prevalence is much higher than current estimates

November 27, 2017
New research indicates that the prevalence of arthritis in the United States has been substantially underestimated, especially among adults

Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis

November 20, 2017
Maintaining sufficient vitamin D levels may help to prevent the onset of inflammatory diseases like rheumatoid arthritis, research led by the University of Birmingham has discovered.

Old World monkeys could be key to a new, powerful rheumatoid arthritis therapy

November 16, 2017
In the quest for a new and more effective treatment for rheumatoid arthritis, researchers from the Keck School of Medicine of USC looked to a primate that mostly roams the land in Asia, the Middle East and Africa. It was ...

Study lists foods for fighting rheumatoid arthritis symptoms and progression

November 8, 2017
A list of food items with proven beneficial effects on the progression and symptoms of rheumatoid arthritis is provided in a new study published today in Frontiers in Nutrition. The authors suggest incorporating these foods ...

Prototype equipment can detect rheumatoid arthritis

September 28, 2017
According to a first clinical study published in the scientific journal Photoacoustics, the University of Twente and various European partners have designed a device that shows the difference between healthy fingers and arthritic ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.