Listening to favorite music improves endothelial function in CAD

September 1, 2013, European Society of Cardiology

Listening to favorite music improves endothelial function in patients with coronary artery disease, according to research presented at ESC Congress 2013 today by professor Marina Deljanin Ilic from Serbia. Music and exercise training combined produced the most benefit.

Professor Deljanin Ilic said: "In the setting of and cardiovascular disease the loses its normal function.1 Since endothelium derived nitric oxide is necessary to maintain an adequate , correction of has become a goal of therapy."

She added: "Exercise training has been shown to improve and is the cornerstone of a multifaceted programme of cardiovascular rehabilitation. However, little is known about the role of music in cardiovascular rehabilitation or the effects of listening to favourite music on endothelial function."

The current study evaluated the effects of listening to favourite music on endothelial function through changes of circulating blood markers of endothelial function: the stable end products of nitric oxide (NOx), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and xanthine oxidase (XO) in 74 patients with stable CAD.

Patients were randomised to trained (T, n=33), music and trained (MT, n=31) and music (M, n=10) groups. Patients in the T and MT groups underwent 3 weeks of supervised training at a residential centre. In addition to exercise training, patients in the MT group listened to their favourite music for 30 minutes every day.

Patients in the M group received usual community care and listened to their favourite music for 30 minutes every day. Markers were measured and an performed at baseline and 3 weeks.

After 3 weeks the value of NOx increased in groups T (from 33.0±13.0 to 42.8±11.0 µmol/l, p< 0.005) and MT (from 34.5±7.1 to 49.6±12.6 µmol/l, p<0.0005) (table 1). The increase in NOx was higher in the MT group than in the T and M groups (p=0.0246 and p<0.005) and in the T than in the M group (p<0.05).

XO significantly decreased in all 3 groups after 3 weeks (p<0.0005 for all groups), but at the end of the study XO was significantly lower in the MT than in the T and M groups (p<0.005 and p<0.0005) and in the T than in the M group (p<0.001). After 3 weeks exercise capacity had increased by 39% in MT, 29% in T and 19% in M compared to baseline values (table 2). ADMA and SDMA decreased in all 3 groups (most pronounced in MT) after 3 weeks but the findings were not significant.

Professor Deljanin Ilic said: "The combination of music and exercise training led to the most improvement in endothelial function. Improvements in endothelial function were associated with significant improvements in exercise capacity."

She added: "Listening to joyful music for 30 minutes has been associated with improved endothelial function, possibly by ?-endorphin mediated activation of endothelium derived .2 The vascular health benefits of music may be due to endorphins or endorphin like compounds released from the brain when we hear music we like."

Professor Deljanin Ilic concluded: "Listening to favourite music alone and in addition to regular improves endothelial function and therefore may be an adjunct method in the rehabilitation of patients with CAD. There is no an 'ideal' music for everybody and patients should choose music which increases positive emotions and makes them happy or relaxed."

Explore further: Short-term smoking cessation reverses endothelial damage

More information: 1 Widlansky ME, Gokce N, Keaney JF, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003;42:1149-1160.

2 Miller M, Mangano CC, Beach V, Kop WJ, Vogel RA. Divergent effects of joyful and anxiety-provoking music on endothelial vasoreactivity. Psychosom Med. 2010;72(4):354-356.

Related Stories

Short-term smoking cessation reverses endothelial damage

September 1, 2013
Eight weeks of smoking cessation reverses the endothelial damage caused by smoking, according to research presented at the ESC Congress today by Dr. Yasuaki Dohi from Japan. Serotonin remained elevated, suggesting eight weeks ...

From birdsong to heavy metal: How cancer patients use music to work through their feelings

July 17, 2013
Very few treatments or therapies endured by cancer patients can be described as pleasant, but a study published in Arts & Healt shows the positive impact of using music as a personal coping method when faced with the disease.

Music reduces anxiety in cancer patients

August 10, 2011
(Medical Xpress) -- Cancer patients may benefit from sessions with trained music therapists or from listening to music. A new Cochrane systematic review shows using music can reduce anxiety in cancer patients, and may also ...

Vitamin D supplementation does not appear to reduce blood pressure in patients with hypertension

August 12, 2013
Vitamin D supplementation does not appear to improve blood pressure or markers of vascular health in older patients with isolated systolic hypertension (a common type of high blood pressure), according to a study by Miles ...

Teen driver music preferences increase errors and distractibility, study finds

August 23, 2013
Teens listening to their preferred music while driving commit a greater number of errors and miscalculations, according to a new study from Ben-Gurion University of the Negev researchers that will be published in the October ...

Simvastatin blunts benefits of exercise in overweight, obese

June 28, 2013
(HealthDay)—Cholesterol-lowering therapy with simvastatin reduces the physiological responses to aerobic exercise training in overweight or obese adults who are at increased risk for metabolic syndrome, according to research ...

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.