Researchers identify a brain 'switchboard' important in attention and sleep

August 14, 2014
An illustration of awake and asleep. Credit: Michael Halassa, M.D., Ph.D.

Researchers at NYU Langone Medical Center and elsewhere, using a mouse model, have recorded the activity of individual nerve cells in a small part of the brain that works as a "switchboard," directing signals coming from the outside world or internal memories. Because human brain disorders such as schizophrenia, autism, and post-traumatic stress disorder typically show disturbances in that switchboard, the investigators say the work suggests new strategies in understanding and treating them.

In a study to be published in the journal Cell online Aug. 14, a team led by Michael Halassa, MD, PhD, assistant professor of psychiatry, neuroscience and physiology, and a member of the NYU Neuroscience Institute, showed how neurons in the thalamic reticular nucleus (TRN)—the so-called switchboard—direct sensory signals such as vision from the outside world, and internal information such as memories, to their appropriate destinations.

"We have never been able to observe as precisely how this structure worked before," says Dr. Halassa. "This study shows us how information can be routed in the brain, giving us tremendous insight into how it might be broken in psychiatric disorders."

For the study, researchers used a multi-electrode technique to record the activity of individual neurons in the TRN, a thin layer of that covers the thalamus, a structure in the forebrain that relays information to the cerebral cortex, the seat of higher-level functions such as learning and language. TRN cells are known to send inhibitory signals to the thalamus, determining which information is blocked.

The activity of TRN cells, the researchers found, depended on whether the mouse was asleep or awake and alert. TRN cells that controlled sensory input were far more active during , particularly during the periods of sleep when brief bursts of fast-cycling brain waves, called spindles, occur. Sleep spindles, which are associated with blocking sensory input during sleep, are known to be diminished among people with autism and schizophrenia.

The video will load shortly
Michael Halassa, M.D., Ph.D. discusses his work with the thalamic reticular nucleus (TRN) and it's importance in identifying new targets for treating various psychiatric disorders like schizophrenia, autism and post-traumatic stress disorder. Credit: NYU Langone Medical Center

Dr. Halassa says the new findings suggest that faulty TRN cells may be disrupting the appropriate filtering of information in these conditions. His group is now exploring this filtering process in animal models of and autism.

In experiments with alert mice, Dr. Halassa's group found that sensory TRN cells fired very little. This suggested that while these neurons block the flow of external information during sleep, they facilitate the flow of information when an animal is awake and alert.

By contrast, TRN cells that control the flow of internal signals behaved in an opposite fashion, firing very little in sleep. This lowered level of activity, Dr. Halassa suspects, may allow memories to form, which is known to occur during sleep. The thalamus has nerve connections to the hippocampus, which plays an important role in learning and memory.

Scientists used mice to study how nerve cells in thalamic reticular nucleus work during sleep and how they help the brain concentrate. Credit: Courtesy of Michael Halassa, M.D., Ph.D., NYU Langone Medical Center.

In a second part of the study, Dr. Halassa's group employed a technique called optogenetics, which uses light to turn nerve cells on and off, to test whether altering TRN nerve cell firing affected attention behavior in the mice.

In one experiment, mice learned to associate a visual stimulus with food. Well-rested mice took just a second or two to find food when a stimulus was presented, while sleep-deprived mice took much longer. By turning on TRN cells that specifically controlled the visual part of the thalamus, as would happen normally in sleep, the rested mice behaved like they were sleep deprived. On the other hand, when the researchers turned off these TRN , sleep-deprived mice quickly found the food.

The video will load shortly
Scientists studied how just a few nerve cell in the mouse brain may control the switch between internal thoughts and external distractions. Using optogenetics, a technique that uses light-sensitive molecules to control nerve cell firing, the scientists were able to switch on and off drowsiness in mice. Credit: Video courtesy of the Halassa lab, NYU Langone Medical Center and NINDS.

"With a flick of a light switch, we seemed able to alter the mental status of the mice, changing the speed at which can travel in the brain," says Dr. Halassa. Mapping brain circuits and disrupting their pathways will hopefully lead to new treatment targets for a range of neuropsychiatric disorders, he adds.

Explore further: Sleep after learning strengthens connections between brain cells and enhances memory

More information: Halassa et al. "State-dependent architecture of thalamic reticular sub-networks," Cell, August 14, 2014. DOI: 10.1016/j.cell.2014.06.025

Related Stories

Sleep after learning strengthens connections between brain cells and enhances memory

June 5, 2014
In study published today in Science, researchers at NYU Langone Medical Center show for the first time that sleep after learning encourages the growth of dendritic spines, the tiny protrusions from brain cells that connect ...

Crossing the channel: Surprising new findings in the neurology of sleep and vigilance

December 30, 2013
(Medical Xpress)—A recent neurological addressing one of the most fundamental issues in sleep rhythm generation study underscores an inconvenient truth—namely, that established scientific facts have and will continue ...

Memory accuracy and strength can be manipulated during sleep

April 8, 2014
The sense of smell might seem intuitive, almost something you take for granted. But researchers from NYU Langone Medical Center have found that memory of specific odors depends on the ability of the brain to learn, process ...

Scientists identify the switch that says it's time to sleep

February 19, 2014
The switch in the brain that sends us off to sleep has been identified by researchers at Oxford University's Centre for Neural Circuits and Behaviour in a study in fruit flies.

Sleep boosts production of brain support cells

September 3, 2013
Sleep increases the reproduction of the cells that go on to form the insulating material on nerve cell projections in the brain and spinal cord known as myelin, according to an animal study published in the September 4 issue ...

Recommended for you

Cognitive cross-training enhances learning, study finds

July 25, 2017
Just as athletes cross-train to improve physical skills, those wanting to enhance cognitive skills can benefit from multiple ways of exercising the brain, according to a comprehensive new study from University of Illinois ...

Lutein may counter cognitive aging, study finds

July 25, 2017
Spinach and kale are favorites of those looking to stay physically fit, but they also could keep consumers cognitively fit, according to a new study from University of Illinois researchers.

Zebrafish study reveals clues to healing spinal cord injuries

July 25, 2017
Fresh insights into how zebrafish repair their nerve connections could hold clues to new therapies for people with spinal cord injuries.

Brain stimulation may improve cognitive performance in people with schizophrenia

July 24, 2017
Brain stimulation could be used to treat cognitive deficits frequently associated with schizophrenia, according to a new study from King's College London.

New map may lead to drug development for complex brain disorders, researcher says

July 24, 2017
Just as parents are not the root of all their children's problems, a single gene mutation can't be blamed for complex brain disorders like autism, according to a Keck School of Medicine of USC neuroscientist.

Working around spinal injuries: Rehabilitation, drug treatment lets rats recover some involuntary movement

July 24, 2017
A new study in rats shows that changes in the brain after spinal cord injury are necessary to restore at least some function to lower limbs. The work was published recently in the journal eLife.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.