Adult stem cell types' heart repair potential probed

November 25, 2016, University of Otago
Dr Rajesh Katare. Credit: University of Otago

New University of Otago research is providing fresh insights into how a patient's adult stem cells could best be used to regenerate their diseased hearts.

The study, led by Department of Physiology researcher Dr Rajesh Katare, is the first to compare the cardiac repair potential of three types of from an individual patient.

In recent years, the approach of harvesting and transplanting a patient's own stem cells to help repair has garnered much interest internationally. However, determining the best cell type to use remains a large challenge.

To help overcome this challenge, Dr Katare and his team used cultured stem cells from 14 patients undergoing coronary artery bypass graft surgery to compare the function of three types of . Two were from the patient's heart itself – the left ventricle and the right atrium – while the third was from the circulating blood of the same patient.

After simulating the conditions of low oxygen levels and lack of nutrients present in heart disease, he and his colleagues then studied the therapeutic effects each of the three stem cell types in repairing the damaged .

They found that the right atrial stem cells had the greatest protective effect on , while the ventricular stem cells were the most effective at promoting the formation of new blood vessels.

The third cell type, , was also equally effective at promoting blood vessel growth, but these cells' potential to be cultivated outside of the body and to migrate to the site of injury in heart cells was found to be significantly lower.

Dr Katare says that if the findings can be replicated in clinical trials, this would suggest a need for personalised stem cell therapy depending on the type of heart disease present in a patient.

"Our findings also provide a possible explanation for several failed clinical trials in stem cells therapy," he says.

The study, which was supported by grants from the J&C Anderson Trust and the Heart Foundation of New Zealand, appears in the International Journal of Cardiology.

Explore further: Sub-set of stem cells found to minimize risks when used to treat damaged hearts

More information: Parul Dixit et al, Progenitor cells from atria, ventricle and peripheral blood of the same patients exhibit functional differences associated with cardiac repair, International Journal of Cardiology (2017). DOI: 10.1016/j.ijcard.2016.11.178

Related Stories

Sub-set of stem cells found to minimize risks when used to treat damaged hearts

July 25, 2016
Scientists use mathematical modeling to simulate human mesenchymal stem cell delivery to a damaged heart and found that using one sub-set of these stem cells minimises the risks associated with this therapy. The study, published ...

Lab-grown stem cells regenerate monkey hearts: study

October 10, 2016
In a step forward for organ regeneration, stem cells grown from a single monkey's skin cells revitalised the damaged hearts of five sick macaques, scientists reported Monday.

A tool for isolating progenitor cells from human heart tissue could lead to heart repair

October 7, 2015
A*STAR researchers and colleagues have developed a method to isolate and expand human heart stem cells, also known as cardiac progenitor cells, which could have great potential for repairing injured heart tissue.

Can 'off the shelf' stem cell therapy treat heart failure patients? UB researcher aims to find out

March 16, 2015
After a heart attack, cardiac stem cell therapy stimulates the growth of new heart cells, but exactly how that happens is unclear. The National Institutes of Health has awarded a $2 million grant to a researcher at the University ...

New method for producing heart cells may hold the key to treating heart failure

March 3, 2016
Scientists at the Gladstone Institutes have discovered how to make a new type of cell that is in between embryonic stem cells and adult heart cells, and that may hold the key to treating heart disease. These induced expandable ...

Novel stem cell approach promising for heart failure

August 3, 2015
(HealthDay)—A new method for delivering stem cells to damaged heart muscle has shown early promise in treating severe heart failure, researchers report online July 27 in Stem Cells Translational Medicine.

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.