Three brain chemicals affect how we handle uncertainty

Three brain chemicals affect how we handle uncertainty
Brain chemicals and their role in how we deal with uncertainty. Credit: Edvard Munch and Roland Roberts

New research has revealed how three important brain signaling chemicals affect the way that we handle uncertainty. It turns out that noradrenaline regulates our estimates of how unstable the environment is, acetylcholine helps us adapt to changing environments, and dopamine pushes us to act on our beliefs about uncertainty. The research, publishing 15 November in the open-access journal PLOS Biology, was led by Louise Marshall and Dr Sven Bestmann at the UCL (University College London) Institute of Neurology.

The study involved 128 healthy participants who took part in a reaction-time task designed to test how they handled . Participants were all given either a placebo or a drug to block noradrenaline, acetylcholine or before starting the task. Participants responded to symbols that were presented one after the other by pressing a corresponding button. The probability of each appearing was dependent on the symbol that appeared previously; for example, if a participant had just seen symbol A, there was an 85% chance that symbol B would appear next. Every 50 trials, these probability patterns changed without warning, so had to detect these new patterns and adjust their responses accordingly.

Lead author Louise Marshall said: "Interacting with our dynamic and ever-changing requires us to frequently update our beliefs about the world. By learning the relationships that link events occurring in our environment, we can predict future events, and execute fast, accurate responses. However, the environment's complex dynamics give rise to uncertainty about the relationships between events, and uncertainty about the stability of these relationships over time.

Several brain chemicals have been proposed to modulate how we handle uncertainty. Here we combined pharmacological interventions and novel computational models to determine how noradrenaline, acetylcholine and dopamine enable our brains to learn the changing relationships in our environment. The results shed important light on how humans learn to behave under uncertainty."


Explore further

Uncertainty can cause more stress than inevitable pain

More information: Marshall L, Mathys C, Ruge D, de Berker AO, Dayan P, Stephan KE, et al. (2016) Pharmacological Fingerprints of Contextual Uncertainty. PLoS Biol 14(11): e1002575. DOI: 10.1371/journal.pbio.1002575
Journal information: PLoS Biology

Citation: Three brain chemicals affect how we handle uncertainty (2016, November 15) retrieved 13 April 2021 from https://medicalxpress.com/news/2016-11-brain-chemicals-affect-uncertainty.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
831 shares

Feedback to editors

User comments