Scientific discovery opens new possibilities for cancer and fibrosis treatment

Scientific discovery opens new possibilities for cancer and fibrosis treatment
Credit: University of Turku

Researchers from the Turku Centre for Biotechnology (BTK) in Finland have discovered that a cellular fuel sensor, known to control energy processes in the cells, is involved in the regulation of the contact of cells with their surrounding environment. This unexpected link could help scientists better understand life-threatening diseases, such as cancer and tissue fibrosis.

The researchers found that a cellular fuel sensor called AMPK controls integrin function and the production of .

"This is a significant finding, since the rather cheap and widely used drug called metformin activates the AMPK sensor in particular and inhibits diabetes, cancer, fibrosis and cardiovascular diseases, and promotes longevity. Our discovery opens up new therapeutic opportunities for the treatment of these diseases," says Academy Professor Johanna Ivaska, senior author of the study.

The space between the of human tissues is filled with a meshwork of different proteins called the extracellular . The cells are connected with the extracellular matrix through protein complexes called adhesions. The main proteins in those adhesions are the integrins which link the cytoskeleton with its environment. The researchers have found that in the absence of the fuel sensor AMPK, fibroblasts activate their integrins increasing their adhesion and matrix production. This increase is attributed to a protein called tensin.

"AMPK is known to control energy homeostasis. In our study, we have shown that this fuel sensor can also regulate integrin signaling and matrix formation, suggesting that AMPK serves as a general master switch in our body. Our aim was to identify potential novel targets to treat diseases associated with excessive matrix formation, such as cancer and fibrotic diseases which are major causes of morbidity and mortality worldwide," reports Maria Georgiadou, first author of the work.

The findings were published in the internationally renowned Journal of Cell Biology on 13 March 2017.

Explore further

Changes of the cell environment are associated with certain eye diseases

More information: Maria Georgiadou et al, AMPK negatively regulates tensin-dependent integrin activity, The Journal of Cell Biology (2017). DOI: 10.1083/jcb.201609066
Journal information: Journal of Cell Biology

Provided by University of Turku
Citation: Scientific discovery opens new possibilities for cancer and fibrosis treatment (2017, March 29) retrieved 4 December 2021 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors