Does brain tissue regeneration depend on maturity of stem cells used for transplantation?

September 13, 2017
Credit: Mary Ann Liebert, Inc., Publishers

New research has shown that the success of transplanting stem cells into the brain to regenerate tissue damaged by stroke may depend on the maturity of the neuronal precursor cells used for transplantation. A study demonstrating the significant impact of human neuronal precursor cell maturity on cell survival after transplantation into stroke-injured rate brains is published in Tissue Engineering, Part A.

Coauthors Samantha Payne, Priya Anandakumaran, Cindi Morshead, and Molly Shoichet, University of Toronto and Balazs Varga and Andras Nagy, Mount Sinai Hospital, Toronto, Canada, evaluated the survival of three subpopulations of human induced (iPC)-derived neuronal precursor : early-, mid-, and late-differentiated cells. Significantly more early- and mid-differentiated neuronal stem cells were present in the rat brains one week after transplantation compared to late-differentiated cells. Furthermore, the mid-differentiated cells were the most likely to mature and become neurons, according to the results reported in the article entitled "In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain."

"Temporality as a variable in has rarely been explored. This is an excellent addition to our understanding of cell behavior in a therapeutic circumstance," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.

Explore further: Selecting most effective materials for dental pulp tissue engineering

More information: Samantha L. Payne et al, In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain, Tissue Engineering Part A (2017). DOI: 10.1089/ten.tea.2016.0515

Related Stories

Selecting most effective materials for dental pulp tissue engineering

August 23, 2017
To regenerate dental pulp tissue after emptying of a tooth's root canals researchers compared the effectiveness of 3D scaffolds made of natural or customized synthetic materials containing pulpal stem cells and dentin-derived ...

Transplantation with induced neural stem cells improves stroke recovery in mice

October 11, 2016
In a study to determine whether induced neural stem cells (iNSCs), a type of somatic cell directly differentiated into neural stem cells, could exert therapeutic effects when transplanted into mice modeled with ischemic stroke, ...

First evidence of ischemia-induced multipotent stem cells in post-stroke human brain

May 3, 2017
Researchers have shown that following a stroke-induced ischemic injury to the human brain, stem cells are produced that have the potential to differentiate and mature to form neurons that can help repair the damage to the ...

Researchers engineer 3-D hydrogels for tissue-specific cartilage repair

July 26, 2017
Unlike the one-size-fits-all, homogeneous approach to tissue engineering for cartilage replacement, a new study reports the ability to encapsulate cartilage-forming chondrocytes and mesenchymal stem cells in 3D hydrogels ...

Making metabolically active brown fat from white fat-derived stem cells

March 3, 2017
Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat metabolic diseases such as obesity and type 2 diabetes, from white adipose-derived stem cells (ASCs). The ...

Neural stem cell therapies could eventually play a role in treating spinal cord injuries

May 4, 2017
Researchers in Qatar and Egypt, working with colleagues in Italy and the US, have found that injured spinal cords in rats show signs of tissue regeneration several weeks following injection with neural stem cells.

Recommended for you

Scientists find key to regenerating blood vessels

November 23, 2017
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels. The ...

Surprising roles for muscle in tissue regeneration, study finds

November 22, 2017
A team of researchers at Whitehead has illuminated an important role for different subtypes of muscle cells in orchestrating the process of tissue regeneration. In a paper published in the November 22 issue of Nature, they ...

Study reveals new mechanisms of cell death in neurodegenerative disorders

November 22, 2017
Researchers at King's College London have discovered new mechanisms of cell death, which may be involved in debilitating neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

How rogue immune cells cross the blood-brain barrier to cause multiple sclerosis

November 21, 2017
Drug designers working on therapeutics against multiple sclerosis should focus on blocking two distinct ways rogue immune cells attack healthy neurons, according to a new study in the journal Cell Reports.

New simple test could help cystic fibrosis patients find best treatment

November 21, 2017
Several cutting-edge treatments have become available in recent years to correct the debilitating chronic lung congestion associated with cystic fibrosis. While the new drugs are life-changing for some patients, they do not ...

Researchers discover key signaling protein for muscle growth

November 20, 2017
Researchers at the University of Louisville have discovered the importance of a well-known protein, myeloid differentiation primary response gene 88 (MyD88), in the development and regeneration of muscles. Ashok Kumar, Ph.D., ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.