Integration of smoking cessation within CT lung cancer screenings shows life-saving results

October 16, 2017, International Association for the Study of Lung Cancer

A study that integrated robust smoking cessation programs into an organized low-dose CT (LDCT) lung cancer screening program found that the inclusion of both interventions has the potential to decrease mortality rates while being relatively cost-effective. Dr. William Evans of McMaster University in Canada presented these findings today at the International Association for the Study of Lung Cancer (IASLC) 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan.

Previous studies had shown that LDCT screening for smokers at high-risk of developing cancer can reduce lung specific and overall . Based on findings from a retrospective analysis, smoking cessation likely plays a role in this mortality reduction. In light of these developments, Dr. Evans and his team decided to undertake their own research in this area.

The researchers used a microsimulation model called OncoSim-LC. OncoSim-LC is led and supported by The Canadian Partnership Against Cancer with model development by Statistics Canada, and is made possible by funding from Health Canada. Using the model, the researchers compared screening without an accompanying cessation program to screening scenarios with cessation interventions, projected over 20 years. Cost-effectiveness was estimated based on a lifetime horizon, health system perspective and 1.5% discount rate. Costs were reported in 2016 Canadian dollars.

Analyzing the results from the OncoSim-LC model, the researchers determined that adding a cessation program to an organized LDCT screening program could cost $14,000/quality-adjusted life-years gained, even over multiple attempts at smoking cessation, and result in significantly fewer deaths.

"To achieve the maximal benefits of a LDCT screening program, it is essential to incorporate a robust smoking intervention," said Dr. Evans. "In my long career as an oncologist, I have not been able to save any patients from advanced non-small cell . I believe that an organized lung program can be used to provide teachable moments for heavy smokers and, ultimately, save lives."

Some questions remain concerning how these joint programs would look in practice. More implementation research needs to be conducted in order to determine the exact economic requirements, ensure participant adherence to both types of intervention and analyze other logistical trade-offs. However, these research results are promising and offer hope for more lives to be saved.

Explore further: Smokers who receive CT lung screening are more likely to quit

Related Stories

Smokers who receive CT lung screening are more likely to quit

July 24, 2017
Smokers who undergo a CT scan of their lungs are more likely to quit than those who don't, concludes a trial led by Cardiff University.

Statement published on pairing smoking cessation with lung cancer screening

March 29, 2016
Researchers, including an associate professor from the Medical University of South Carolina Hollings Cancer Center, say smokers who go to a doctor to be screened for lung cancer should also be encouraged to quit smoking during ...

Lung cancer screening could save money as well as lives, research shows

June 29, 2017
Lung cancer screening is likely to be cost-effective, particularly if it also identifies other tobacco-related conditions in high-risk people, suggests new research published in the Journal of Thoracic Oncology (JTO).

Lung cancer screening found cost-effective for Medicare

October 3, 2014
(HealthDay)—Low-dose computed tomography (LDCT) is a low-cost and cost-effective strategy for screening Medicare beneficiaries for lung cancer, according to a study published in the August issue of American Health & Drug ...

Study highlights importance of regular lung cancer screenings for those at high risk

August 18, 2016
Lung cancer is the leading cause of cancer death for men and women. It is also one of the most complex cancers, both at the molecular level and through its clinical behavior. Screening is paramount as it helps physicians ...

Screening could avert 12,000 lung cancer deaths each year in the US

February 25, 2013
Screening for lung cancer with low-dose computed tomography (LDCT) in all screening-eligible current and former smokers has the potential to avert approximately 12,000 lung cancer deaths each year in the United States. That ...

Recommended for you

Biologists discover how pancreatic tumors lead to weight loss

June 20, 2018
Patients with pancreatic cancer usually experience significant weight loss, which can begin very early in the disease. A new study from MIT and Dana-Farber Cancer Institute offers insight into how this happens, and suggests ...

Researchers find 11 genes responsible for the spread of cancer

June 20, 2018
A groundbreaking discovery by University of Alberta researchers has identified previously-unknown therapeutic targets that could be key to preventing the spread of cancer.

'Kiss of death' cancer: How computational geeks may have uncovered a therapy for a deadly disease

June 19, 2018
It's called the 'kiss of death'. Triple negative breast cancer has no targeted drug therapy and, as such, the only hope for these patients is chemotherapy. Triple negative breast cancer is aggressive and deadly. Patients ...

Team discovers gene mutations linked to pancreatic cancer

June 19, 2018
Six genes contain mutations that may be passed down in families, substantially increasing a person's risk for pancreatic cancer. That's according to Mayo Clinic research published in the June 19 edition of the JAMA. However, ...

Ovarian cancer cells switched off by 'unusual' mechanism

June 19, 2018
Scientists at the Ovarian Cancer Action Research Centre at Imperial College London have discovered a mechanism that deactivates ovarian cancer cells.

Breast cancer could be prevented by targeting epigenetic proteins, study suggests

June 19, 2018
Researchers at the Princess Margaret Cancer Centre in Toronto have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study, which will ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.