Scientists have improved the cell incubator for human organs

May 8, 2018 by Tanya Arsenyeva, Tomsk State University
Incubator made of thin filaments of titanium nickelide (TiNi). Credit: Tomsk State University

TSU has patented a new incubator made of thin filaments of titanium nickelide (TiNi) for introducing cells into the injured human body. It is designed to compensate for functions damaged by trauma or disease. Thanks to the new production method, the incubator has become more durable and now accommodates more cellular structures, which makes it 150 percent more efficient.

A permeable incubator in medicine is a porous container for cells that are used to completely or partially replace the functions of a damaged organ. This container is impregnated with a suspension of the cell culture that will replace the dead cells of the organ, and then is placed in the human body. Diseases of the liver, pancreas, and hematopoietic system and other diseases are treated In this way.

TSU scientists proposed making the incubator in a new way: not from a solid array but from intertwined filaments of titanium nickelide with a diameter of 25 to 40 microns. Thanks to this solution, it accommodates 150 percent more functioning cells with the same volume. In addition, it increases its permeability, and hence, the fillability of the cell suspension.

"Our incubator is made in three versions: in the form of crumpled tangled filaments; in the form of a multilayer tampon made of woven mesh of filaments; and in the form of (a balled-up roll of nickel-titanium mesh," explains Professor Victor Gunter, director of the TSU Research Institute of Medical Materials and Implants with Shape Memory. "Such an incubator is very strong and flexible, and therefore it does not injure tissues that come in contact with it in unforeseen mechanical stresses, for example, impacts or falls."

Scientists have improved the cell incubator for human organs
Incubator for introducing cells into the injured human body. Credit: Tomsk State University

The interweaving of filaments in the incubator forms many local micro-dimensional niches, where the fragments of the cell culture hide from the attack of of the body. This also happens because the size of immune cells exceeds the dimensions of filaments from titanium nickelide.

"After a period of adaptation, the inside the incubator begin to , replacing partially or completely the function of the injured organ and creating a certain therapeutic effect," adds Georgy Dambayev, a professor at Siberian State Medical University. Over time, the efficiency of the device increases, as the permeable structure germinates with blood and lymphatic vessels, and the incubator functions as closely as possible to natural organs in natural conditions.

The lifetime of the from the filaments is 150 percent longer than that of the incubators from the array of porous nickel titanium.

Explore further: See how immune cells break through blood vessel walls

Related Stories

See how immune cells break through blood vessel walls

January 17, 2017
In any given second, thousands of immune cells are poking holes in your blood vessels as they travel out of the blood stream to survey your organs for problems or join the fight against a pathogen. Despite the constant assault, ...

Recommended for you

Best of Last Year—The top Medical Xpress articles of 2017

December 20, 2017
It was a good year for medical research as a team at the German center for Neurodegenerative Diseases, Magdeburg, found that dancing can reverse the signs of aging in the brain. Any exercise helps, the team found, but dancing ...

Pickled in 'cognac', Chopin's heart gives up its secrets

November 26, 2017
The heart of Frederic Chopin, among the world's most cherished musical virtuosos, may finally have given up the cause of his untimely death.

Sugar industry withheld evidence of sucrose's health effects nearly 50 years ago

November 21, 2017
A U.S. sugar industry trade group appears to have pulled the plug on a study that was producing animal evidence linking sucrose to disease nearly 50 years ago, researchers argue in a paper publishing on November 21 in the ...

Female researchers pay more attention to sex and gender in medicine

November 7, 2017
When women participate in a medical research paper, that research is more likely to take into account the differences between the way men and women react to diseases and treatments, according to a new study by Stanford researchers.

Drug therapy from lethal bacteria could reduce kidney transplant rejection

August 3, 2017
An experimental treatment derived from a potentially deadly microorganism may provide lifesaving help for kidney transplant patients, according to an international study led by investigators at Cedars-Sinai.

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.