Better way to transplant human stem cells

Better way to transplant human stem cells
hES cells were differentiated into NPC or cerebral organoids. Stereotactic surgery was performed to transplant one single cerebral organoid in the lesioned frontoparietal cortex in postnatal day 8-10 mice. For NPC transplantation, dissociated NPC were implanted into identical cortical region by stereotactic injection. Credit: Daviaud et al., eNeuro (2018)

A tissue-like structure created from human stem cells and implanted into a damaged region of the mouse brain improves cell survival and differentiation relative to conventional, cell-based methods. The research, published in eNeuro, encourages further investigation of this strategy and its potential to treat traumatic brain injury and neurodegeneration.

Hongyan Zou and colleagues compared two methods for transplanting human into the frontoparietal cortex of young mice, part of which was removed. The researchers report that growing cells into a miniature, brain-like organoid for just over a month into was superior to transplanting individual . The three-dimensional structure may have helped shield transplanted cells from the damaged host brain to promote their survival.

These findings, together with a previous study demonstrating the feasibility of a similar cell replacement technique, provides a new way to study human brain development and disease progression in the laboratory. They also warrant consideration of the ethical issues associated with the development of cerebral organoids for therapeutic purposes.

More information: Vascularization and engraftment of transplanted human cerebral organoids in mouse cortex, eNeuro, DOI: 10.1523/ENEURO.0219-18.2018

Citation: Better way to transplant human stem cells (2018, November 12) retrieved 24 September 2023 from
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