Potential way to treat and prevent cancer in children with neuroblastoma

**Research Team Discover a Potential Way to Treat and Prevent Cancer in Children with Neuroblastoma
Photos of Professor Michelle Haber AM Executive Director of Children's Cancer Institute Australia Credit: Children’s Cancer Institute Australia

The MYCN oncogene has long been known to be a key cause of a number of deadly solid tumour cancers, including neuroblastoma, which claims more lives of children under the age of 5 than any other cancer.

Neuroblastoma is the most common solid tumour found in . In up to 25% of cases, the tumours contain an increased number of copies of MYCN, and children with these 'high-risk' neuroblastomas have a particularly poor prognosis.

To date, no drugs have been able to directly target MYCN, so scientists have looked at other ways to halt the progress of .

One group of target molecules, known as polyamines, are known to be critical for and survival and are present in high concentrations in cancer cells. However, of agents that target the pathway have proven disappointing.

In new research published this week in the international journal, Science Translational Medicine, a team jointly led by Professor Michelle Haber AM, Executive Director, and Professor Murray Norris AM, Deputy Director, Children's Cancer Institute, Australia, has uncovered a previously unknown and crucial link between polyamines and MYCN, revealing that the polyamine pathway is entirely regulated by the MYCN oncogene.

Discovering this link – by which MYCN controls polyamine levels in , driving the growth and proliferation of the neuroblastoma cells – means that scientists for the first time have a potential therapeutic "way in" to disrupting cancer cell growth.

Previously, the Children's Cancer Institute research team has shown that a drug called DFMO targets a gene involved in the synthesis of polyamines. There is currently a clinical trial underway at the Kids Cancer Centre, Sydney Children's Hospital, and in 14 leading US children's cancer centres, to study the use of DFMO when given with existing anti-cancer drugs, to treat children with relapsed neuroblastoma.

In the current study, researchers have identified the gene responsible for the uptake of polyamines by neuroblastoma cells and have shown that this gene can be inhibited using a drug called AMXT-1501. By combining these two drugs, DFMO and AMXT-1501, with conventional chemotherapy, the research team was able to significantly increase survival in mice with established neuroblastoma tumours, as well as prevent tumour formation in mice who were tumour-free but genetically prone to developing the disease.

The newly discovered is now being tested in the US in adult patients with a broad range of cancers, in Phase 1 clinical trials run by pharmaceutical company Aminex Therapeutics. The trial is listed on the NIH clinical trial registry at www.clinicaltrials.gov (Identifier NCT03536728).

"This exciting new treatment approach warrants clinical investigation in children with MYCN-driven high-risk neuroblastoma, and potentially other cancers as well," said Haber. "While other treatment approaches in clinical evaluation are designed to inhibit polyamine synthesis, they do not impact polyamine uptake from the microenvironment. Our study suggests that both polyamine synthesis and polyamine uptake need to be inhibited for therapy to be effective."

Mark Burns Ph.D., President and Chief Scientific Officer at Aminex and an author on the paper, described the study's results as "impressive" and said they further bolster the company's excitement about the potential for polyamine depletion therapy as a new treatment approach. "These findings demonstrate the benefit of combining inhibition of polyamine synthesis with blockade of polyamine transport and suggest that combining AMXT 1501 and DFMO with standard chemotherapy may be a potent treatment strategy for high-risk neuroblastoma patients," he said.

Working with Aminex Therapeutics to lead the introduction of this new combination treatment for neuroblastoma into clinical is Associate Professor David Ziegler, paediatric oncologist at the Sydney Children's Hospital and a research Group Leader at the Children's Cancer Institute.

"These results are very exciting and offer a new and potent way to target childhood cancers," said Ziegler. "We have already shown in our current clinical trial that targeting polyamines with one drug (DFMO) can be safely achieved in combination with chemotherapy. By combining two drugs targeting the same pathway we have the potential to further improve the anti- effect for these children. We are now working with Aminex to develop a children's formulation of AMXT1501 and once the initial adult trial is complete, we plan to open a clinical trial for children with the most aggressive cancers."


Explore further

Finding new combination therapies for neuroblastoma

More information: Laura D. Gamble et al. Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma, Science Translational Medicine (2019). DOI: 10.1126/scitranslmed.aau1099
Journal information: Science Translational Medicine

Provided by Aminex Therapeutics, Inc.
Citation: Potential way to treat and prevent cancer in children with neuroblastoma (2019, January 31) retrieved 19 September 2019 from https://medicalxpress.com/news/2019-01-potential-cancer-children-neuroblastoma.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
13 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more