Researchers create organoid of a brain region to study cognitive disorders

Researchers create organoid of a brain region to study cognitive disorders
Credit: Yale University

In a lab dish, Yale researchers modeled two brain structures and their interactions to shed light on the origins of neuropsychiatric diseases.

In-Hyun Park, associate professor of genetics, and his team created an organoid of the thalamus, a major hub that integrates and relays it to different areas of the brain. Organoids are created from to mimic brain areas and assess their function. The lab was interested in the thalamus because it has been implicated in several .  The thalamic organoid was then fused with an organoid of the frontal cortex, the seat of higher cognitive function.

"Right now we are trying to utilize the thalamic organoid to study epilepsy, , schizophrenia and even depression. With many of these diseases, people have found that there are some defects in the coritco-thalamic connectivity, as well as microstructural changes in the thalamus."

By creating organoids from cells taken directly from patients, the specifics of the structural changes underlying each disease could be discovered and personalized treatments developed.

The research was published in the journal Cell Stem Cell.


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Modular approach found to improve consistency of organoids

More information: hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids. Cell Stem Cell. DOI: doi.org/10.1016/j.stem.2018.12.015
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Citation: Researchers create organoid of a brain region to study cognitive disorders (2019, February 22) retrieved 21 March 2019 from https://medicalxpress.com/news/2019-02-organoid-brain-region-cognitive-disorders.html
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Feb 22, 2019
Would these brain organelles suffer?
I like the idea of these two organoids meeting up like this, scary but comforting

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