Sound-frequency map for inner ear created with advanced X-ray technology

Sound-frequency map for inner ear created with advanced X-ray technology
Ear membrane and auditory nerve in the cochlea. The octave bands have been given different colours. Humans can perceive frequencies from 20 Hz (the top of the coil) to 20,000 Hz (the base of the coil). The image also shows the round window, the oval window where sound enters and the facial nerve. Credit: Hao Li

Researchers at Uppsala University have created the first 3-D map of the auditory nerve, showing where the various sound frequencies are captured. Using what is known as synchrotron X-ray imaging, they were able to trace the fine nerve threads and the vibrating auditory organ, the cochlea, and find out exactly how the frequencies of incoming sound are distributed. The study is published in Scientific Reports.

"This can make treatment with cochlear implants for the hearing impaired more effective," says Helge Rask-Andersen, professor of experimental otology at Uppsala University.

Sound waves have differing frequencies—that is, the number of vibrations they make every second varies according to whether it is a high-pitched sound, which causes more vibrations per second, or a low-pitched one, which results in fewer. Frequency is measured in hertz (Hz), and the can perceive frequencies of between 20 and 20,000 Hz.

When the are captured by the cochlea of the inner ear, fibrous connective tissue and separate the frequencies. High-frequency sounds reach the -sensitive hair in the lower part of the cochlea, while low-frequency sounds are absorbed in the corresponding way in the upper parts of the cochlea.

The researchers have now studied the details of this process, almost down to cell level. To do so, they used synchrotron X-rays, an advanced and powerful form of tomographic imaging. Since the radiation is too strong to be used on living human beings, donated ears from deceased people were investigated instead. This research has made it possible to work out the locations of the frequencies in the cochlear , and enabled the creation of a three-dimensional tonotopic frequency map.

"This kind of map is comparable to a piano, with the keys being analogous to all the similarly coded frequencies. Unlike the piano, which has 88 keys, we have about 3,400 internal auditory hair cells, all of which encode distinct frequencies. The hair cells are attached to a 34-millimeter-long basilar membrane, and are also tuned by 12,000 outer hair cells so that we can hear every volume level. This information is mediated to the brain via 30,000 precisely tuned fibers in our hearing nerve," Helge Rask-Andersen explains.

Human ear canals and nerves are not entirely uniform in appearance. The researchers therefore think the new knowledge may prove immensely important for people who, owing to grave hearing impairments, have (CIs). A CI is a hearing aid with one component placed in the cochlea to provide direct electrical stimulation of the auditory nerve, while another part is attached to the outside of the skull. Showing exactly what the patient's looks like enables the technology to be individualized better and each area stimulated with the right frequency.

More information: Hao Li et al., Three?dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase?contrast imaging, Scientific Reports. DOI: 10.1038/s41598-021-83225-w

Journal information: Scientific Reports
Provided by Uppsala University
Citation: Sound-frequency map for inner ear created with advanced X-ray technology (2021, February 24) retrieved 22 February 2024 from
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