Research team reads minds to understand human tool use
Researchers at the University of East Anglia have made an astonishing discovery about how our brains control our hands.
They used MRI data to study which parts of the brain are used when we handle tools, such as a knives.
They read out the signal from certain brain regions and tried to distinguish when participants handled tools appropriately for use.
Humans have used tools for millions of years, but this research is the first to show that actions such grasping a knife by its handle for cutting are represented by brain areas that also represent images of human hands, our primary 'tool' for interacting with the world.
The research could pave the way for the development of next-generation neuroprosthetics—prosthetic limbs that tap into the brain's control centre, and help rehabilitate people who have lost function in their limbs due to brain injury.
The study was led by UEA and carried out at the Norfolk and Norwich University Hospital.
Lead researcher Dr. Stephanie Rossit, from UEA's School of Psychology, said: "The emergence of handheld tools marks the beginning of a major discontinuity between humans and our closest primate relatives and is considered a defining feature of our species. Our findings could shed light on the regions of the brain that specifically evolved in the humans."
"We knew that seeing images of tools activates a different region of the brain to when we see other kinds of objects, for example a chair.
"Until now it was assumed that the brain segregates visual information in this way to optimize processing of actions associated with tools. But how the human brain controls our hands to correctly grasp 3D objects such as tools was not well understood.
"We wanted to test whether the human brain automatically processes 3D objects in terms of how we grasp them for use. And we particularly wanted to find out whether we could use signals from specific parts of the brain to distinguish whether people were handling tools correctly—for example grasping a knife by the handle rather than the blade."
The team used an MRI scanner to collect brain imaging data while participants interacted with 3D objects.
Dr. Rossit said: "This was really challenging because the space inside the scanner is really small and the participants need to stay really still.
"So we used a one-of-a-kind 'real action' set-up for presenting 3D tools and other objects.
"Our participants lay in the dark, on a custom-built bed with a revolving table mounted above their waist, so that we could show them 3D objects and they could grasp them.
"We designed and 3D-printed everyday kitchen tools from non-magnetic materials so that they would be safe in the MRI such as a plastic knife, pizza cutter and a spoon as well as another group of 3D-printed bars to represent items that were not tools, which we used as control objects."
Dr. Ethan Knights, who was a Ph.D. student with Dr. Rossit, coordinated the data collection and scanned the brains of 20 volunteers at the Norfolk and Norwich University Hospital. In the first session, participants were asked to grasp the 3D tool and 3D bars correctly or incorrectly using the bespoke 'real action' set-up.
The same participants returned to the scanner for a second session in which they simply looked at pictures of tools and hands.
Dr. Fraser Smith, also from UEA's School of Psychology, said: "We studied brain activity when participants viewed pictures of tools and hands to identify which parts of the brain where the brain hand picture is represented.
"We then used state of the art machine learning to see if we could predict whether people actually grasped a tool by its handle or not. This is really important because knowing not to grasp an object, like a knife, by its blade, is critical to successful tool-use.
Dr. Rossit said: "In contrast to what most scientists thought, we were able to predict whether a tool was grasped correctly from the signals of brain areas that respond to the sight of pictures of hands and not from visual areas that respond to the sight of pictures of tools.
"Importantly the signals from the visual hand areas could only be used to predict hand actions with tools but could not predict matched actions with the control 3D bar objects.
"This suggests that the visual hand areas are specially tuned for actions with tools.
"Our discovery changes our fundamental understanding of how the brain controls our hands and could have important implications for health and society.
"For example, it could help develop better devices or rehabilitation for people who have lost function in their limbs due to brain injury. And it could even allow people without limbs to control prosthetics with their minds.
"The potential for brain-driven interfaces and prosthetics is very exciting," she added.
"Hand-selective visual regions represent how to grasp 3D tools: brain decoding during real actions" is published in the Journal of Neuroscience on May 10, 2021. The study was funded by the BIAL Foundation.