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New strategy intercepts pancreatic cancer by eliminating microscopic lesions before they become cancer
A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors. Using an experimental therapy to target microscopic precancerous lesions in the ...
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Calcium signaling channels regulate neuroinflammation and motivation, research reveals
Northwestern Medicine scientists have discovered how calcium signaling channels in microglia—the primary immune cells of the brain—regulate neuroinflammation and promote the development of behaviors associated with affective ...
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Medical research news
First-of-its-kind analysis reveals the structural variant landscape driving pediatric cancer development
The first and largest dataset of genomic structure variations specific to childhood cancers was published today by scientists from St. Jude Children's Research Hospital and the National Cancer Institute. The researchers assembled ...
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Tuning T cells' cancer-killing power via an engineered hydrogel platform
Lymph nodes, considered the command centers of our immune system, often get swollen and stiff when fighting infection. Now, a UC Berkeley-led team of researchers has discovered that this mechanical change may help instruct ...
1 hour ago
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Overlooked brainstem pathway that controls human hands offers stroke therapy targets
Researchers have identified a network of connections linking the brainstem and spinal cord that helps control hand and arm movements, revealing an unexpected layer of the nervous system enabling people to grasp, hold, and ...
1 hour ago
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A single dose of psilocybin is more effective than nicotine patches for quitting smoking, study suggests
A new study, published in JAMA Network Open, reports the outcome of a clinical trial out of Johns Hopkins University assessing the effectiveness of psilocybin as a treatment for smokers attempting to quit. The trial compared ...
Power outages linked to more emergency hospital visits for older adults
Adults over age 65 experience greater numbers of emergency hospitalizations for cardiovascular and respiratory diseases during and after power outages, reports a new study by Heather McBrien of Columbia Mailman School of ...
2 hours ago
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Watching a lifetime in motion reveals the architecture of aging
By midlife, an animal's everyday behaviors can signal how long it is likely to live. That is the striking conclusion of a new study in which researchers put scores of short-lived fish under continuous, lifelong surveillance ...
2 hours ago
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Scientists find a new therapeutic target present on up to half of all tumors
For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden ...
2 hours ago
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Immune cells in the brain may tune fertility hormones, animal study suggests
The kick-off signal for puberty begins in the brain. Specifically, in the hypothalamus, where specific neurons release a hormone that activates the hypophysis, at the base of the skull, which then releases other hormones ...
2 hours ago
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Sleep apnea aggravates muscle loss in people with COPD, research shows
Chronic obstructive pulmonary disease (COPD) is known for causing breathing difficulties and limiting everyday activities. Obstructive sleep apnea syndrome (OSAS), on the other hand, is usually associated with loud snoring ...
1 hour ago
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AI-driven tool significantly personalizes antidepressant treatment, international trial finds
An AI-driven tool that tailors antidepressant treatment to individual patients was shown to improve outcomes for people with depression, compared to standard treatment, in a major international trial. It is the first time ...
3 hours ago
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Federal drug price reforms are improving medication adherence, new study finds
More than 1 in 4 U.S. adults struggle to afford their prescription medications. Those who can't are left with grim choices—such as skipping doses, cutting pills in half, or abandoning prescriptions entirely—that can come ...
3 hours ago
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Certain neurons are especially susceptible to ALS and frontotemporal dementia, researchers discover
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) belong to a spectrum of neurodegenerative diseases with overlapping symptoms, characterized by muscle wasting, paralysis, dementia, and other serious impairments. ...
4 hours ago
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High-fat diet-linked dysbiosis may send gut bacteria to the brain via vagus nerve
Gut dysbiosis caused by a high-fat diet can allow bacteria to move from the gut to the brain in mice, according to a new study by David Weiss and Arash Grakoui from Emory University, U.S., and colleagues published in the ...
2 hours ago
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Anchoring a key immune molecule makes T cells hit harder
Researchers at the Kennedy Institute of Rheumatology have found that physically resisting the formation of an immunological synapse actually promotes a stronger immune response. The findings could help explain how immune ...
4 hours ago
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A new reagent makes living brains transparent for deeper, non-invasive imaging
Making a living brain transparent and watching its neurons fire without disturbing their function—sounds like science fiction, doesn't it? Yet the solution may already exist within our own bodies. In a paper published in ...
10 hours ago
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How bacteria suppress immune defenses in stubborn wound infections
Researchers have revealed how a common bacterium, Enterococcus faecalis (E. faecalis), releases lactic acid to acidify its surroundings and suppress the immune-cell signal needed to start a proper response to infection. By ...
3 hours ago
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Novel tool measures how cancer cells rewrite genetic instructions to aid growth and survival
Cancer is caused by faulty genes, but what also shapes a cancer cell's behavior is how a gene's instructions are trimmed and rearranged before they are turned into the proteins that keep a cell alive. A study published in ...
11 hours ago
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Major genetic risk factor for rare form of dementia identified
Researchers at VIB and Antwerp University have identified a major genetic risk factor for a rare form of frontotemporal dementia. The discovery, published today in Nature Genetics, provides a biological entry point for a ...
5 hours ago
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