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Oncology & Cancer
Genetic mutations in HRAS, KRAS genes linked to childhood cancers
Hereditary changes in genes are often the cause of rare diseases. For example, disease-causing gene variants (PVs) in the HRAS gene cause Costello syndrome and PVs in the KRAS gene cause Noonan syndrome and cardio-facio-cutaneous ...
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Arthritis & Rheumatism
Study offers potential for early diagnosis and therapeutic intervention for rheumatoid arthritis
Currently, there are no cures for rheumatoid arthritis (RA), which affects 40,000 people in Ireland. The disease costs an estimated $22,000 per patient, per year with an overall cost to the health system of ~$608 million. ...
1 hour ago
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Medical research news
Study confirms effectiveness of the new omicron booster
The autumn wave of coronavirus is sweeping across Germany. Those affected mainly suffer from coughs, colds, sore throats and fever, but also from headaches, aching limbs, general weakness and shortness of breath. Because ...
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Discovery of important blood pressure 'switch'—how some cells remember to make renin
University of Virginia School of Medicine researchers have discovered how certain cells have the amazing ability to transform their function to help our bodies control our blood pressure.
1 hour ago
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Researchers uncover unexpected role of hippocampus in skilled movement control
Researchers at the University of Birmingham have uncovered a surprising role of the hippocampus—linking this part of the brain to the control of skilled actions such as handwriting, typing, and playing music.
1 hour ago
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A faulty iron hormone in the skin may be the root cause of psoriasis
Scientists may have uncovered the root cause of psoriasis, a chronic and sometimes debilitating skin disease that affects 2–3% of the global population. The condition is characterized by red, scaly patches that impact the ...
3 hours ago
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Right-side deep brain stimulation may preserve verbal fluency in Parkinson's patients
Deep brain stimulation is an effective treatment for motor symptoms in patients with movement disorders such as Parkinson's disease. While ultimately regarded as safe, DBS can yield noticeable declines in verbal fluency, ...
1 hour ago
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Nanobodies help decode the central mechanism of inflammation
The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine ...
1 hour ago
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Researchers discover new bacterium that causes gut immunodeficiency
Cleveland Clinic researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases.
3 hours ago
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The gut microbiome can influence hormone levels, mouse study shows
Researchers at the Francis Crick Institute have shown that the balance of bacteria in the gut can influence symptoms of hypopituitarism in mice. They also showed that aspirin was able to improve hormone deficiency symptoms ...
3 hours ago
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Synthetic compound shows promise against drug-sensitive, drug-resistant strains of human malaria parasites
In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite. For decades, the parasite's resistance to all antimalarial drugs ...
3 hours ago
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Maternal cannabis use linked to genetic changes in babies
Novel research suggests cannabis use during pregnancy is directly linked to negative impacts on babies' brain development.
2 hours ago
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Rates of sudden unexpected infant death changed during the COVID-19 pandemic, study finds
The risk of sudden unexpected infant death (SUID) and sudden infant death syndrome (SIDS) increased during the COVID-19 pandemic compared to the pre-pandemic period, especially in 2021, according to a new study led by researchers ...
5 hours ago
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Genetic background of pregnant women can influence non-invasive prenatal test results
Non-invasive prenatal tests (NIPTs) are increasingly an integral part of screening during pregnancies across the world. Research from Amsterdam UMC shows that a pregnant woman's genetic background influences the effectiveness ...
5 hours ago
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Signs of developing asthma are evident in the first year of life, health data analysis shows
What factors lead to chronic respiratory disease? Researchers investigated this question using health data from about 780 infants. Their analysis shows that children's risk of developing asthma later in life can be more reliably ...
5 hours ago
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How are stretch reflexes modulated during voluntary movement?
How did the bodies of animals, including ours, become such fine-tuned movement machines? How vertebrates coordinate the eternal tug-o-war between involuntary reflexes and seamless voluntary movements is a mystery that Francisco ...
3 hours ago
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Metabolic reprogramming of T cells may enhance checkpoint inhibitor therapy
Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study led by researchers at Weill Cornell ...
5 hours ago
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A 'Google Earth' view of bone—with an eye toward disease prevention
Everyone knows that we can view the broad structures of our bones in the body by taking X-rays. Yet that's just scratching the surface. Science now has a host of new imaging and characterization techniques to go deeper, and ...
5 hours ago
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Organoids derived from gut stem cells reveal two distinct molecular subtypes of Crohn's disease
Crohn's disease—an autoimmune disorder—is characterized by chronic inflammation of the digestive tract, resulting in a slew of debilitating gastrointestinal symptoms that vary from patient to patient. Complications of ...
5 hours ago
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Cognitive deficits from meth and PCP use are generated by a common neurotransmitter switch, neurobiologists show
The effects of sustained drug abuse can manifest in many ways. Loss of memory and reduced cognitive functions are some of the effects that can persist for years. Neurobiologists at the University of California San Diego have ...
6 hours ago
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