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Neuroscience
Opioid abuse can change the brain
"This is your brain on drugs," the old anti-drug admonition says, and now a new study has found there's something to that chestnut.
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Oncology & Cancer
GDF-15 inhibitors show promise against hard-to-treat tumors in clinical trial
A multi-institutional clinical trial led by the University of Navarra, Spain, found that blocking growth differentiation factor 15 (GDF-15) can counteract resistance to anti-PD-1 and anti-PD-L1 therapies in solid tumors.
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Medical research news
Melanoma survival linked to tumor thickness
Researchers at The University of Sydney have identified a significant increase in melanoma-related death risk for patients with thin primary tumors measuring between 0.8 and 1.0 millimeters compared to those with thinner ...
Refrigerated raw milk harbors infectious flu virus for 5 days, study finds
Raw milk, hailed by some as a natural and nutritious alternative to pasteurized dairy, may come with hidden dangers, according to a new Stanford University study. The research, published December 12 in Environmental Science ...
Dec 14, 2024
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HIF1α identified as crucial for T cell activation in oxygen-poor tumors
Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ...
Dec 14, 2024
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Chemotherapy shortage did not increase cancer patient mortality
During a shortage of the generic platinum chemotherapy drugs cisplatin and carboplatin that began in early 2023, there was no difference in mortality rates among patients with advanced cancer compared to the previous year, ...
Dec 14, 2024
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Light-induced gene therapy disables cancer cells' mitochondria
Researchers are shining a light on cancer cells' energy centers—literally—to damage these power sources and trigger widespread cancer cell death. In a new study, scientists combined strategies to deliver energy-disrupting ...
Dec 13, 2024
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AI-powered blood test can spot earliest sign of breast cancer
A new screening method that combines laser analysis with a type of AI is the first of its kind to identify patients in the earliest stage of breast cancer, a study suggests.
Dec 13, 2024
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Some aging cells heal wounds, others cause harm: Study shows how to distinguish between the two
Lengthening life by eliminating old, inflammatory cells is a tantalizing idea, but anti-aging researchers suspect it's oversimplified. Now, University of Connecticut researchers confirm in an article published in the Nov. ...
Dec 13, 2024
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Molecular insights unlock a targeted approach to cancer immunotherapy
Australian-led research is unlocking new ways for immunotherapy to better target cancer. Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer ...
Dec 13, 2024
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An unexpected side effect: Intermittent fasting may slow hair regrowth
Intermittent fasting has proven benefits for metabolic health, but a new study shows that it could slow hair growth—at least in mice. Researchers report December 13 in the journal Cell that mice subjected to intermittent ...
Dec 13, 2024
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AI tool analyzes placentas at birth for faster detection of neonatal and maternal problems
A newly developed tool that harnesses computer vision and artificial intelligence (AI) may help clinicians rapidly evaluate placentas at birth, potentially improving neonatal and maternal care, according to new research from ...
Dec 13, 2024
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From Yemen to France, research reveals spread of highly drug-resistant cholera strain
Scientists from the National Reference Center for Vibrios and Cholera at the Institut Pasteur, in collaboration with the Center hospitalier de Mayotte, have revealed the spread of a highly drug-resistant cholera strain. The ...
Dec 13, 2024
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Microglia: The double-edged sword in Alzheimer's progression
Microglia are known to play an important role in Alzheimer's disease, but exactly what they do has remained a mystery. Scientists in the Bart De Strooper Lab at the VIB-KU Leuven Center for Brain & Disease have unraveled ...
Dec 13, 2024
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Drug screening platform identifies compound for reinvigorating exhausted CAR-T cells
A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed a chimeric antigen receptor T (CAR-T) cell exhaustion model and a functional screening platform ...
Dec 13, 2024
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Photocurrent-responsive coating cuts bone-to-implant integration time in half
A research team has developed an innovative photocurrent-responsive implant surface to accelerate bone-to-implant integration after orthopedic surgery. The cutting-edge coating has been shown to shorten the integration time ...
Dec 13, 2024
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Key genetic mechanism provides insights into facial development and congenital issues
An international team of researchers has identified a key genetic mechanism that regulates the formation and migration of cranial neural crest cells, which are essential for developing facial structures.
Dec 13, 2024
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Mini-brains reveal how mitochondrial mutations affect brain cells
Researchers at the University of Bergen have used advanced stem cell technology to develop mini-brains, also called brain organoids, that can mimic disease processes caused by mitochondrial failure. This could open new avenues ...
Dec 13, 2024
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Gut-immune connection could boost immunotherapy effectiveness in recurrent ovarian cancer
A study led by Roswell Park Comprehensive Cancer Center provides new insight into the complex interactions of the "tumor-immune-gut axis," and its role in influencing immunotherapy responses in patients with recurrent ovarian ...
Dec 13, 2024
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How DNA shapes reproductive health, fertility and even life expectancy
Led by researchers from the University of Oxford's Leverhulme Center for Demographic Science and the University of Iceland, a review, published in Nature Aging, explores how genetic variations can explain differences in reproductive ...
Dec 13, 2024
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