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Study finds tumor growth fueled by nucleotide salvage

Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children's Medical Center Research Institute ...

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Study highlights association between urinary and vaginal pathogenic E. coli in recurrent cystitis

The human body hosts a diverse array of microorganisms that maintain a delicate balance crucial for overall health. This microbial harmony can be disrupted by factors such as infections, aging, and hormonal changes, leading ...

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Protein droplets likely don't cause Parkinson's, study suggests

Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson's disease, shows a recent study. Rather, the formation of protein into liquid droplets may help to dissolve ...

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PFAS shown to reduce the activity of immune cells

PFAS are used in many everyday products. This is because PFAS are water- and fat-repellent, heat resistant, and extremely durable. PFAS have been produced since the 1950s and there are now around 10,000 different compounds.

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Researchers identify proteins associated with deadly burns

Although many people still die from severe burns, the underlying physiology behind burns is not well understood. In an article published in iScience, researchers from Osaka University identified key proteins associated with ...

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Analysis: Most research on PFAS harms is unpublicized

Though per- and polyfluoroalkyl substances (PFAS) make headlines daily, a new paper reveals that most studies finding links between PFAS exposure and human health harms are published without a press release and receive little ...

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Benchmarking AI's ability to answer medical questions

A benchmark for assessing how well large language models (LLMs) can answer medical questions is presented in a paper published in Nature. The study, from Google Research, also introduces Med-PaLM, an LLM specialized for the ...

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AI brings hope for patients with lysosomal storage disease

Artificial intelligence is becoming increasingly important in drug discovery. Advances in the use of Big Data, learning algorithms and powerful computers have now enabled researchers at the University of Zurich (UZH) to better ...

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Researchers solve structure of immune-evading HIV protein complex

The HIV-1 virus can neutralize cellular defenses with its viral infectivity factor (Vif). OIST researchers Prof. Matthias Wolf and Dr. Takahide Kouno together with an international team of colleagues have now determined the ...

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Researchers uncover signal needed for blood-brain barrier

What makes the vital layer of protective cells around the brain and spinal cord—the blood-brain barrier—more or less permeable has been one of the more mystifying questions in neuroscience.

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A step toward treating chemotherapy-resistant prostate cancer

Prostate cancer is a leading cause of death among American men, and it's resistant to one of the most powerful chemotherapy medications—cisplatin. Now, researchers reporting in ACS Central Science have developed the first ...

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Historical medicine suggests a new way to use modern treatments

The mixture of honey and vinegar, also known as oxymel, has been used as a medical treatment throughout history and now scientists have established that this combination could have modern applications in the treatment of ...

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Doctors warn of looming threat to America's surgical research

Surgeons who also conduct important biomedical research are struggling to obtain research funding, and that "broken pipeline" could spell extinction for surgeon-scientists and slow innovations for patients if something isn't ...