Neuroscience

Brain research reveals a circuit for cocaine relapse

Approximately 1.5 million Americans use cocaine in a given year, according to the National Institute on Drug Abuse. Many are repeat users. Unfortunately, there are currently no FDA-approved medicinal treatments for cocaine ...

Psychology & Psychiatry

Women's hormones play role in drug addiction, higher relapse rates

Women's hormonal cycles may not only make them more prone to drug addiction but also more affected by triggers that lead to relapse, a new Vanderbilt University study revealed. The findings are especially significant since ...

Psychology & Psychiatry

Cocaine adulterant may cause brain damage

People who regularly take cocaine cut with the animal anti-worming agent levamisole demonstrate impaired cognitive performance and a thinned prefrontal cortex. These findings from two recent studies at the University of Zurich ...

Genetics

Gene therapy via skin protects mice from lethal cocaine doses

There are no approved medications to treat either cocaine addiction or overdose. Frequent users tend to become less and less sensitive to the drug, leading to stronger or more frequent doses. The typical result is addiction. ...

Neuroscience

Cocaine relapse is reversed with BDNF microinjections in the brain

Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor (BDNF) was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators ...

Neuroscience

Researchers identify protein involved in cocaine addiction

Mount Sinai researchers have identified a protein produced by the immune system—granulocyte-colony stimulating factor (G-CSF)—that could be responsible for the development of cocaine addiction.

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