Current diagnostic methods do not always reliably distinguish between chronic inflammation of the pancreas and pancreatic cancer. About one third of all diagnoses are inconclusive. Scientists from the German Cancer Research ...
Sep 20, 2023
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A new paper titled "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease" has been published in Aging.
Sep 18, 2023
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New research has found the most common form of breast cancer presents differing metabolic signatures in the blood of African American women with estrogen receptor-positive breast cancer compared with non-Hispanic white women. ...
Sep 11, 2023
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Researchers investigated the relationship between historical traumatic events experienced by Alaska Native communities and epigenetic markers on genes that previous studies have linked to trauma. The new study found a similar ...
Sep 7, 2023
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Depression is a common mental health problem that affects people across demographics. Scientists have long known that there may be a genetic component that confers predisposition to depression, but the specific underlying ...
Sep 7, 2023
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Bacteria lurking in human digestive system can assist growth of stomach tumors, say researchers from the University of Sharjah, the United Arab Emirates.
Sep 6, 2023
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Preeclampsia is a severe complication of pregnancy, affecting one in 40 pregnant women. Identifying high-risk patients is often difficult and complex because the exact cause of preeclampsia is still unknown.
Aug 29, 2023
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Scientists at The Wistar Institute have discovered a potential target for gastric cancers associated with Epstein-Barr Virus, and their study results are published in the journal mBio.
Aug 22, 2023
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"Should I be taking a probiotic?" is a question that Maggie Stanislawski, Ph.D., assistant professor in the University of Colorado Department of Biomedical Informatics (DBMI), gets asked often.
Aug 17, 2023
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A deafened adult cannot recover the ability to hear, because the sensory hearing cells of the inner ear don't regenerate after damage. In two new studies, published in the Proceedings of the National Academy of the Sciences ...
Aug 14, 2023
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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation is a common capability of all viruses for self non-self identification, the epigenetic code could be a persistent remnant of ancient viral infection events.
DNA methylation involves the addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring — in this case with the specific effect of reducing gene expression. DNA methylation at the 5 position of cytosine has been found in every vertebrate examined. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.
In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide but guanine.
Research has suggested that long term memory storage in humans may be regulated by DNA methylation.
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