When fighting chronic viral infections or cancers, a key division of the immune system, known as CD8 T cells, sometimes loses its ability to effectively fight foreign invaders. Overcoming so-called T cell exhaustion is crucial ...
Feb 12, 2015
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Craniofacial birth defects, including cleft lip and palate, are among the most common human congenital malformations. Now, FMI researchers have identified a DNA region containing multiple regulatory elements that interact ...
Jun 6, 2023
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The two most common types of inflammatory bowel disease are ulcerous colitis and Crohn's disease. These are diagnosed via endoscopy and gut biopsy. The diagnosis is often difficult, and the wrong diagnosis may have severe ...
Apr 27, 2018
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Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 million base pairs away from ...
May 8, 2023
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Researchers at the University of Washington have determined that the majority of genetic changes associated with more than 400 common diseases and clinical traits affect the genome's regulatory circuitry. These are the regions ...
Sep 5, 2012
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Cells face a daunting task. They have to neatly pack a several meter-long thread of genetic material into a nucleus that measures only five micrometers across. This origami creates spatial interactions between genes and their ...
Mar 8, 2017
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Identifying mutations in the control switches of genes can be a surprisingly accurate way to predict a person's medical history, researchers at the Stanford University School of Medicine have found.
Feb 4, 2016
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A flurry of coordinated activity in a brain-spanning network of neurons may sound like the formation of a brilliant new idea, but it is actually the description of a seizure. Understanding why and how this synchronization ...
Sep 13, 2016
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(Medical Xpress)—More than a million people die each year of malaria caused by different strains of the Plasmodium parasite transmitted by the Anopheles mosquito. The medical world has yet to find an effective vaccine against ...
Dec 3, 2012
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The parasitic disease leishmaniasis is found primarily in Central and South America, the Mediterranean region, the Middle East, and Central Asia and is transmitted to humans by a sand fly. An estimated 1.5 million new cases ...
Oct 24, 2023
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