Researchers identify a metabolite as a biomarker of diabetes risk

Type 2 diabetes (T2D) is the most common form of diabetes and is associated with many complications. T2D is preventable through weight control and exercise; however, many individuals are unaware that they are at risk and do not change their lifestyle in time to avoid disease.

In this issue of the Journal of Clinical Investigation, Robert Gerszten and colleagues at Massachusetts General Hospital identify the metabolite 2-aminoadipic acid (2-AAA) as a biomarker for T2D diabetes risk. Individuals with increased levels of 2-AAA had a much greater risk of developing diabetes than individuals with lower 2-AAA levels.

The authors found that this metabolite was present in at-risk individuals up to 12 years before to T2D onset. Additionally, addition of 2-AAA to isolated pancreatic cells from both mice and humans enhanced .

This study provides a biomarker of T2D risk that is a potential for the regulation of glucose homeostasis.

More information: 2-Aminoadipic acid is a biomarker for diabetes risk, J Clin Invest. DOI: 10.1172/JCI64801

add to favorites email to friend print save as pdf

Related Stories

Genetic predisposition to diabetes ups risk of CVD

Oct 23, 2012

(HealthDay)—For patients with type 2 diabetes (T2D), having a genetic predisposition towards the disease is associated with an increased risk of cardiovascular disease (CVD), according to a study published ...

Genetic risks for type 2 diabetes span multiple ethnicities

Feb 09, 2012

A recent large and comprehensive analysis of 50,000 genetic variants across 2,000 genes linked to cardiovascular and metabolic function has identified four genes associated with type 2 diabetes (T2D) and six independent disease-associated ...

Insulin secretion disrupted by increased fatty acids

Sep 09, 2013

Patients with type 2 diabetes have increased levels of circulating glucose and fatty acids, which lead to disease complications. In healthy individuals, β cells within pancreatic islets release insulin in response to glucose ...

Genetic clues for type 2 diabetes

Aug 14, 2012

Busselton residents and researchers from The University of Western Australia have contributed to a worldwide scientific collaboration that has identified new genetic links in the quest to map the biological ...

Recommended for you

Screening for diabetes at dental visits using oral blood

Feb 26, 2015

It is estimated that 8.1 million of the 29.1 million Americans living with diabetes are undiagnosed and many who have diabetes have poor glycemic control. Given that each year many Americans visit a dental provider but not ...

CBT, sertraline insufficient in diabetes and depression

Feb 26, 2015

(HealthDay)—For patients with diabetes and depression, improvements in depression are seen with cognitive behavioral therapy (CBT) or sertraline, with a significant advantage for sertraline, but glycemic ...

Early signs in young children predict type 1 diabetes

Feb 26, 2015

New research shows that it is possible to predict the development of type 1 diabetes. By measuring the presence of autoantibodies in the blood, it is possible to detect whether the immune system has begun to break down the ...

Daily menu plan reduces blood sugar significantly

Feb 25, 2015

A large group of people with diabetes who followed a menu plan created by University of Alberta nutrition researchers for just three months significantly reduced their blood sugar levels.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.