Page 4 - Chromatin - Medical News and Research Articles

Scientists discover new Achilles heel of leukemia cells

Leukemia is the most common type of cancer in children. Treatment involves intensive chemotherapy, which has severe side effects due to its non-specific mode of action.

Nov 20, 2023

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Mutations in tumor cells discovered to be frequently associated with DNA–RNA hybrids

A study by the University of Seville, CABIMER and IRB Barcelona led by the researchers Andrés Aguilera (US-CABIMER) and Aleix Bayona Feliu (IRB Barcelona) raises the possibility that DNA–RNA hybrids and the mutations in various ...

Nov 16, 2023

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Researchers find an epigenetic key that unlocks common deadly cancers

Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as a single layer of epidermal progenitor cells. Their choice is to become a mature epidermal cell or ...

Jul 28, 2023

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Mapping the development of infection-fighting immune cells

The immune system protects the body from invaders, such as bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs. Specialized immune cells, called cytotoxic T cells, can develop into short-lived ...

Jun 13, 2023

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New research may lead to improved insulin-secreting cells derived from stem cells

Diabetes researchers at Washington University School of Medicine in St. Louis have uncovered at least one reason insulin-secreting cells made from stem cells in the lab don't work as well as natural cells. The discovery could ...

May 18, 2023

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New neurodevelopmental disorder identified among patients with common symptoms

A new type of developmental disability caused by mutations in a gene known as CBX1 has been discovered by a UT Southwestern Medical Center researcher and his colleagues. The findings, reported in Genetics in Medicine, offer ...

May 17, 2023

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Gene expression signatures indicate loss of function by master regulators of the genome

Second only to the notorious TP53 gene, the genes for assemblages known as mSWI/SNF protein complexes are the most frequently mutated entities in cancer cells. Made up of 10 to 15 subunits, the complexes are built from the ...

Apr 10, 2023

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Identifying where HIV sleeps in the brain

The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure ...

Mar 16, 2023

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How genome doubling helps cancer develop

A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils. The solution is chromatin: a complex of DNA wrapped around proteins called histones. In the 3D space, this ...

Mar 15, 2023

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Study unravels a cause of resistance to novel drug in patients with acute leukemia

A new targeted drug has not only sparked remissions in patients with a common form of leukemia but also induced the cancer cells to reveal one of their schemes for resisting the drug, investigators at Dana-Farber Cancer Institute ...