Pathophysiology may help ID rare, early form of Alzheimer's

July 12, 2012
Pathophysiology may help ID rare, early form of alzheimer's
In dominantly inherited Alzheimer's disease, clinical and biomarker changes occur decades before the expected onset of disease symptoms, according to a study published online July 11 in the New England Journal of Medicine.

(HealthDay) -- In dominantly inherited Alzheimer's disease, clinical and biomarker changes occur decades before the expected onset of disease symptoms, according to a study published online July 11 in the New England Journal of Medicine.

Randall J. Bateman, M.D., from the Washington University School of Medicine in St. Louis, and colleagues conducted a prospective longitudinal study, analyzing data from 128 participants to examine the order and magnitude of pathologic processes. The participants underwent baseline clinical and cognitive assessments, brain imaging, and (CSF) and blood tests. The participant age at baseline and parental age at the onset of Alzheimer's symptoms were used to estimate the years to .

Twenty-five years before expected symptom onset, the researchers found that the concentrations of amyloid-beta (Aβ)42 in the CSF appeared to decline. Fifteen years before expected symptom onset, Aβ deposition in the brain was detected, as were increased concentrations of tau protein in the CSF and an increase in brain atrophy. Ten years before expected symptom onset, cerebral hypometabolism and impaired episodic memory were observed. Five years before expected symptom onset, global cognitive impairment was detected, as measured by the Mini-Mental State Examination and the Clinical Dementia Rating scale. The diagnostic criteria for dementia were met an average of three years after expected onset of symptoms.

"Autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer's disease, brain amyloid deposition, and brain metabolism as well as progressive cognitive impairment," the authors write.

Several authors disclosed financial ties to pharmaceutical, biotechnology, and diagnostic companies.

Explore further: Study examines relationship between two proteins associated with Alzheimer's disease

More information: Abstract
Full Text

Related Stories

Study examines relationship between two proteins associated with Alzheimer's disease

April 23, 2012
A study that examined the relationship between two cerebrospinal fluid proteins associated with Alzheimer disease in clinically and cognitively normal older patients suggests that amyloid-β (Αβ)-associated ...

Inherited Alzheimer's detectable 20 years before dementia

July 20, 2011
Inherited forms of Alzheimer's disease may be detectable as many as 20 years before problems with memory and thinking develop, scientists will report July 20, 2011, at the Alzheimer's Association International Conference ...

Changes seen in cerebrospinal fluid levels before onset of Alzheimer dementia

January 2, 2012
Cerebrospinal fluid levels of Aβ42 appear to be decreased at least five to 10 years before some patients with mild cognitive impairment develop Alzheimer disease (AD) dementia whereas other spinal fluid levels seem to ...

Advances in research into Alzheimer's disease

July 9, 2011
Advances in research into Alzheimer's disease: transporter proteins at the blood CSF barrier and vitamin D may help prevent amyloid β build up in the brain

Recommended for you

Thinking 'out-of-the-box' may build a better brain and prevent dementia

September 25, 2017
More than 5 million Americans today are affected by Alzheimer's disease (AD). If nothing is done to stop this upward trajectory, there will be more than 16 million people with AD in the United States and more than 60 million ...

Multi-gene test predicts Alzheimer's better than APOE E4 alone

September 22, 2017
A new test that combines the effects of more than two dozen genetic variants, most associated by themselves with only a small risk of Alzheimer's disease, does a better job of predicting which cognitively normal older adults ...

Personality changes don't precede clinical onset of Alzheimer's, study shows

September 21, 2017
For years, scientists and physicians have been debating whether personality and behavior changes might appear prior to the onset of Alzheimer's disease and related dementias.

Newly ID'd role of major Alzheimer's gene suggests possible therapeutic target

September 20, 2017
Nearly a quarter century ago, a genetic variant known as ApoE4 was identified as a major risk factor for Alzheimer's disease—one that increases a person's chances of developing the neurodegenerative disease by up to 12 ...

Is the Alzheimer's gene the ring leader or the sidekick?

September 15, 2017
The notorious genetic marker of Alzheimer's disease and other forms of dementia, ApoE4, may not be a lone wolf.

Potential noninvasive test for Alzheimer's disease

September 6, 2017
In the largest and most conclusive study of its kind, researchers have analysed blood samples to create a novel and non-invasive way of helping to diagnose Alzheimer's disease and distinguishing between different types of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.