Pathophysiology may help ID rare, early form of Alzheimer's

July 12, 2012
Pathophysiology may help ID rare, early form of alzheimer's
In dominantly inherited Alzheimer's disease, clinical and biomarker changes occur decades before the expected onset of disease symptoms, according to a study published online July 11 in the New England Journal of Medicine.

(HealthDay) -- In dominantly inherited Alzheimer's disease, clinical and biomarker changes occur decades before the expected onset of disease symptoms, according to a study published online July 11 in the New England Journal of Medicine.

Randall J. Bateman, M.D., from the Washington University School of Medicine in St. Louis, and colleagues conducted a prospective longitudinal study, analyzing data from 128 participants to examine the order and magnitude of pathologic processes. The participants underwent baseline clinical and cognitive assessments, brain imaging, and (CSF) and blood tests. The participant age at baseline and parental age at the onset of Alzheimer's symptoms were used to estimate the years to .

Twenty-five years before expected symptom onset, the researchers found that the concentrations of amyloid-beta (Aβ)42 in the CSF appeared to decline. Fifteen years before expected symptom onset, Aβ deposition in the brain was detected, as were increased concentrations of tau protein in the CSF and an increase in brain atrophy. Ten years before expected symptom onset, cerebral hypometabolism and impaired episodic memory were observed. Five years before expected symptom onset, global cognitive impairment was detected, as measured by the Mini-Mental State Examination and the Clinical Dementia Rating scale. The diagnostic criteria for dementia were met an average of three years after expected onset of symptoms.

"Autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer's disease, brain amyloid deposition, and brain metabolism as well as progressive cognitive impairment," the authors write.

Several authors disclosed financial ties to pharmaceutical, biotechnology, and diagnostic companies.

Explore further: Study examines relationship between two proteins associated with Alzheimer's disease

More information: Abstract
Full Text

Related Stories

Study examines relationship between two proteins associated with Alzheimer's disease

April 23, 2012
A study that examined the relationship between two cerebrospinal fluid proteins associated with Alzheimer disease in clinically and cognitively normal older patients suggests that amyloid-β (Αβ)-associated ...

Inherited Alzheimer's detectable 20 years before dementia

July 20, 2011
Inherited forms of Alzheimer's disease may be detectable as many as 20 years before problems with memory and thinking develop, scientists will report July 20, 2011, at the Alzheimer's Association International Conference ...

Changes seen in cerebrospinal fluid levels before onset of Alzheimer dementia

January 2, 2012
Cerebrospinal fluid levels of Aβ42 appear to be decreased at least five to 10 years before some patients with mild cognitive impairment develop Alzheimer disease (AD) dementia whereas other spinal fluid levels seem to ...

Advances in research into Alzheimer's disease

July 9, 2011
Advances in research into Alzheimer's disease: transporter proteins at the blood CSF barrier and vitamin D may help prevent amyloid β build up in the brain

Recommended for you

PET scans for Alzheimer's could bring benefit to more patients

October 19, 2017
An imaging tool honed to spot rogue proteins in the brain could benefit some patients with suspected Alzheimer's, according to a new study.

One step closer toward a treatment for Alzheimer's disease?

October 18, 2017
Scientists at the Massachusetts General Hospital (MGH), in collaboration with colleagues at the University California, San Diego (UCSD), have characterized a new class of drugs as potential therapeutics for Alzheimer's disease ...

New mechanism detected in Alzheimer's disease

October 13, 2017
McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer's disease.

Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer's disease

October 13, 2017
Microglia, immune cells that act as the central nervous system's damage sensors, have recently been implicated in Alzheimer's disease.

Green tea extract delivers molecular punch to disrupt formation of neurotoxic species

October 11, 2017
Green tea is widely considered to be beneficial for the brain. The antioxidant and detoxifying properties of green tea extracts help fight catastrophic diseases such as Alzheimer's. However, scientists have never fully understood ...

Menopause triggers metabolic changes in brain that may promote Alzheimer's

October 10, 2017
Menopause causes metabolic changes in the brain that may increase the risk of Alzheimer's disease, a team from Weill Cornell Medicine and the University of Arizona Health Sciences has shown in new research.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.