Mortality similar for single and multiple primary melanomas

June 24, 2013
Mortality similar for single and multiple primary melanomas
Mortality is similar for patients with single primary melanomas (SPMs) and multiple primary melanomas (MPMs), but relative mortality is considerably higher for patients with thicker SPMs versus thicker MPMs, according to a study published online June 19 in JAMA Dermatology.

(HealthDay)—Mortality is similar for patients with single primary melanomas (SPMs) and multiple primary melanomas (MPMs), but relative mortality is considerably higher for patients with thicker SPMs versus thicker MPMs, according to a study published online June 19 in JAMA Dermatology.

Noting that patients with a first primary melanoma are at greater risk of being diagnosed with another, Anne Kricker, Ph.D., from the University of Sydney in Australia, and colleagues compared survival in 2,372 patients with SPMs and 1,206 patients with MPMs of any stage.

After a median follow-up of 7.6 years, the researchers found that thickness was the principal determinant of mortality (hazard ratio, 7.68 for >4 mm). Ulceration, mitoses, and scalp location were also independent predictors of mortality. After adjustment for these factors, mortality was similar for MPM and SPM (hazard ratio for MPM versus SPM, 1.24; P = 0.18). However, relative for thicker was higher for SPM than for MPM (hazard ratio for >4 mm, 13.56 versus 2.93).

"In summary, we found no strong evidence of a difference in survival between SPM and MPM patients despite the evidence of other researchers and suggestions that MPM may have a less aggressive biology than SPM," Kricker and colleagues conclude. "However, to our knowledge, we report for the first time a greater increase in the risk of death with increasing tumor thickness for SPM than for MPM."

Explore further: ATS: Early prone positioning reduces mortality in ARDS

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

ATS: Early prone positioning reduces mortality in ARDS

May 21, 2013
(HealthDay)—For patients with acute respiratory distress syndrome (ARDS), prolonged prone positioning during mechanical ventilation is associated with significantly reduced mortality at 28 and 90 days, according to a study ...

Tumor-Infiltrating lymphocyte grade IDs melanoma survival

June 20, 2012
(HealthDay) -- Tumor-infiltrating lymphocyte (TIL) grade is an independent predictor of melanoma-specific survival and sentinel lymph node (SLN) status in patients with localized primary cutaneous melanoma, according to a ...

Study shows revisions in MPM staging system might be needed in future

October 15, 2012
The International Mesothelioma Interest Group (IMIG) staging system has been widely used, however, widespread concerns exist about the validity of the current malignant pleural mesothelioma (MPM) staging system. Concerns ...

Long-term type 2 diabetes ups pancreatic cancer mortality

August 15, 2012
(HealthDay) -- Among patients with pancreatic adenocarcinoma (PAC), those with pre-existing type 2 diabetes mellitus (T2DM) for longer than five years have an increased mortality risk, according to a study published online ...

Clopidogrel after MI less effective in diabetes patients

September 5, 2012
(HealthDay)—Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue of the Journal ...

Education, wealth levels impact mortality in diabetes patients

January 16, 2013
(HealthDay)—Socioeconomic status, as measured by education and financial wealth, is a strong independent predictor of mortality risk among adult diabetes patients, according to a study published in the January issue of ...

Recommended for you

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

Researchers develop swallowable test to detect pre-cancerous Barrett's esophagus

January 17, 2018
Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise ...

Scientists zoom in to watch DNA code being read

January 17, 2018
Scientists have unveiled incredible images of how the DNA code is read and interpreted—revealing new detail about one of the fundamental processes of life.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.