Living organ regenerated for first time

April 8, 2014, University of Edinburgh
Credit: Wikipedia

Medical procedures that can rejuvenate human body parts have moved a step closer with the completion of a new study.

A team of scientists at the University of Edinburgh has succeeded in regenerating a living organ for the first time.

The team rebuilt the - an organ in the body located next to the heart that produces important immune cells.

Immune repair

The advance could pave the way for new therapies for people with damaged immune systems and genetic conditions that affect thymus development.

The team reactivated a natural mechanism that shuts down with age to rejuvenate the thymus in very old mice. After treatment, the regenerated organ had a similar structure to that found in a young mouse.

Function restored

The function of the thymus was also restored and the mice began making more called T cells, which are important for fighting off infection. However, it is not yet clear whether the of the mice was improved.

The study was led by researchers from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh.

The researchers targeted a protein produced by cells of the thymus - called FOXN1 - which helps to control how important genes are switched on. By increasing levels of FOXN1, the team instructed stem cell-like cells to rebuild the organ.

"Our results suggest that targeting the same pathway in humans may improve thymus function and therefore boost immunity in elderly patients, or those with a suppressed immune system. However, before we test this in humans we need to carry out more work to make sure the process can be tightly controlled." said Clare Blackburn, Professor of Tissue Stem Cell Biology, MRC Centre for Regenerative Medicine

Treatment hope

The thymus deteriorates with age, which is why older people are often more susceptible to infections such as flu.

The discovery could also offer hope to patients with DiGeorge syndrome, a genetic condition that causes the thymus to not develop properly.

"One of the key goals in is harnessing the body's own repair mechanisms and manipulating these in a controlled way to treat disease. This interesting study suggests that organ regeneration in a mammal can be directed by manipulation of a single protein, which is likely to have broad implications for other areas of regenerative biology." said Dr Rob Buckle, Head of Regenerative Medicine, Medical Research Council

The study is published today in the journal Development.

Explore further: Transplanting thymus cells into patients may repair and restore the immune system

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4 comments

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Osiris1
1.7 / 5 (3) Apr 08, 2014
Looking for new therapies to regenerate or improve other organs too. Hope the porn industry does not get wind of this.......heh......heh...
Scottingham
3.5 / 5 (2) Apr 08, 2014
Age is just another disease. We're part of the first generation of humans where the prospect of being able to live forever isn't outright baloney and very well might be around the corner. Not sure anybody would want to though...
TheKnowItAll
3 / 5 (1) Apr 08, 2014
I certainly won't say no to it when it comes if it does in my timeline.
eric_in_chicago
not rated yet Apr 09, 2014
I have been saying for the last ten years, "this is one crappy time to die from cancer when cures are just around the corner!"

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