Living organ regenerated for first time

thymus
Credit: Wikipedia

Medical procedures that can rejuvenate human body parts have moved a step closer with the completion of a new study.

A team of scientists at the University of Edinburgh has succeeded in regenerating a living organ for the first time.

The team rebuilt the - an organ in the body located next to the heart that produces important immune cells.

Immune repair

The advance could pave the way for new therapies for people with damaged immune systems and genetic conditions that affect thymus development.

The team reactivated a natural mechanism that shuts down with age to rejuvenate the thymus in very old mice. After treatment, the regenerated organ had a similar structure to that found in a young mouse.

Function restored

The function of the thymus was also restored and the mice began making more called T cells, which are important for fighting off infection. However, it is not yet clear whether the of the mice was improved.

The study was led by researchers from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh.

The researchers targeted a protein produced by cells of the thymus - called FOXN1 - which helps to control how important genes are switched on. By increasing levels of FOXN1, the team instructed stem cell-like cells to rebuild the organ.

"Our results suggest that targeting the same pathway in humans may improve thymus function and therefore boost immunity in elderly patients, or those with a suppressed immune system. However, before we test this in humans we need to carry out more work to make sure the process can be tightly controlled." said Clare Blackburn, Professor of Tissue Stem Cell Biology, MRC Centre for Regenerative Medicine

Treatment hope

The thymus deteriorates with age, which is why older people are often more susceptible to infections such as flu.

The discovery could also offer hope to patients with DiGeorge syndrome, a genetic condition that causes the thymus to not develop properly.

"One of the key goals in is harnessing the body's own repair mechanisms and manipulating these in a controlled way to treat disease. This interesting study suggests that organ regeneration in a mammal can be directed by manipulation of a single protein, which is likely to have broad implications for other areas of regenerative biology." said Dr Rob Buckle, Head of Regenerative Medicine, Medical Research Council

The study is published today in the journal Development.


Explore further

Transplanting thymus cells into patients may repair and restore the immune system

Journal information: Development

Citation: Living organ regenerated for first time (2014, April 8) retrieved 21 January 2020 from https://medicalxpress.com/news/2014-04-regenerated.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments