Study explores the effects of eating dark chocolate on the brain

Study explores the effects on the brain of eating dark chocolate
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Eating chocolate is typically discouraged by nutritionists, as it is can be high in calories, fat and sugar. Cocoa, however, chocolate's primary ingredient derived from the seed of the cacao plant, has been found to have numerous qualities that could be beneficial for both the body and mind.

Most notably, pure cocoa is highly nutritious and is a powerful source of antioxidants, substances that can prevent or slow down cell damage caused by . Free radicals are unstable and highly reactive molecules produced by the body when responding to , which are associated with aging and disease. In addition, cocoa has been found to help regulate the blood pressure and prevent cognitive decline.

Despite these potentially beneficial properties, rarely contain cocoa alone, but also sugar, oils, butter, and other ingredients that are unhealthy for the body. The healthiest type of chocolate is thus likely to be dark chocolate comprised of high percentages of cocoa.

Elham Kalantarzedeh, Maryam Radahmadi and Parham Reisi, three researchers at Isfahan University of Medical Science in Iran have recently carried out a study on rats investigating the impact of different dark chocolate on synapses in a specific region of the brain, known as the hippocampal CA1 area. Their findings, published in Nutritional Neuroscience, suggest that dark chocolate consumption could have beneficial effects on the brain of individuals exhibiting chronic isolation .

"Although stress causes brain dysfunction, consumption of dark chocolate (DC) has positive effects on brain functions," the researchers wrote in their paper. "The current study investigated the impact of different DC dietary patterns on synaptic potency and plasticity in the hippocampal CA1 area, as well as and body weight in rats under chronic isolation stress."

Essentially, Kalantarzedeh and her colleagues wanted to determine whether eating dark chocolate in different degrees affected the potency and plasticity (i.e., adaptability over time) of synapses (i.e., tiny gaps across which different neurons communicate with each other) in the hippocampal CA1 area.

To do this, they took 35 rats and divided them into five groups of 7, each of which was fed dark chocolate while experiencing chronic isolation stress, with each group following a different dietary pattern. The three dark chocolate dietary patterns they tested were dubbed stress-compulsory, stress-optional and stress-restricted.

"The stressed rats on a compulsory diet only received DC and the ones on an optional diet received unlimited chow and/or DC," the researchers wrote in their paper. "Also, the stressed rats on a restricted diet each received chow freely and only 4 g DC daily. Subsequently, the slope and amplitude of field excitatory postsynaptic potentials (fEPSPs) were assessed based on the Input-Output (I/O) curves and after the long-term potentiation (LTP)."

The researchers also measured the food intake and body weight of the rats they tested on at the beginning and end of their experiment. Interestingly, they found that all the dark dietary patterns reduced both the rats' food intake and their body weight. The strongest effects, however, were those caused by compulsory and restricted dietary patterns.

"The fEPSP slope and amplitude in the I/O curves and after LTP decreased significantly in the stress group compared to the control group," the researchers wrote in their paper. "Although the slope and amplitude both enhanced non-significantly in the optional DC diet, these parameters changed significantly in both compulsory and restricted DC dietary patterns compared to the stress group. Also, food intake and decreased significantly in all DC groups."

Overall, the experiments carried out by this team of researchers suggest that the systematic consumption of could reverse the adverse effects of chronic isolation stress on the synaptic potency and plasticity of the hippocampal CA1 area. This would in turn have beneficial effects on both memory and learning.

As their study was carried out in , however, to be applicable to humans, their findings would need to be validated on a human sample of participants. If their results were confirmed in future studies involving humans, their work would offer evidence of the positive effects of cocoa on the brain and on cognitive abilities.

More information: Elham Kalantarzadeh et al, The impact of different dark chocolate dietary patterns on synaptic potency and plasticity in the hippocampal CA1 area of the rats under chronic isolation stress, Nutritional Neuroscience (2022). DOI: 10.1080/1028415X.2022.2088946

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