Melanoma

Blocking 'scaffold' protein inhibits cancer growth, study finds

(Medical Xpress)—Researchers at the Stanford University School of Medicine have devised an entirely novel way to block biological signaling pathways that, when overactive, lead to many types of cancers. They've done so ...

Cancer created Apr 22, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Study reveals how melanoma evades chemotherapy

Nitric oxide (NO), a gas with many biological functions in healthy cells, can also help some cancer cells survive chemotherapy. A new study from MIT reveals one way in which this resistance may arise, and ...

Cancer created Apr 08, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Immortality gene mutation identifies brain tumors, other cancers

Newly identified mutations in a gene that makes cells immortal appear to play a pivotal role in three of the most common types of brain tumors, as well as cancers of the liver, tongue and urinary tract, according to research ...

Cancer created Mar 18, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

First evidence that obesity gene is risk factor for melanoma

The gene most strongly linked to obesity and overeating may also increase the risk of malignant melanoma – the most deadly skin cancer, reveals research published in Nature Genetics.

Genetics created Mar 04, 2013 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Tumors deliberately create conditions that inhibit body's best immune response

New research in the Journal of Clinical Investigation reveals that tumours in melanoma patients deliberately create conditions that knock out the body's 'premier' immune defence and instead attract a weaker immune respon ...

Cancer created Mar 01, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Researchers discover enzyme behind breast cancer mutations

Researchers at the University of Minnesota have uncovered a human enzyme responsible for causing DNA mutations found in the majority of breast cancers. The discovery of this enzyme – called APOBEC3B – may change the way ...

Cancer created Feb 06, 2013 | popularity 4.5 / 5 (2) | comments 1 | with audio podcast

New mutations driving malignant melanoma discovered

Two new mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the "dark matter" of the cancer genome, where cancer-related mutations haven't ...

Cancer created Jan 24, 2013 | popularity not rated yet | comments 0 | with audio podcast

Drug-resistant melanoma tumors shrink when therapy is interrupted

Researchers in California and Switzerland have discovered that melanomas that develop resistance to the anti-cancer drug vemurafenib (marketed as Zelboraf), also develop addiction to the drug, an observation ...

Cancer created Jan 09, 2013 | popularity 3.7 / 5 (3) | comments 0 | with audio podcast

Research breakthrough could halt melanoma metastasis

In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 ...

Cancer created Nov 14, 2012 | popularity 4.8 / 5 (6) | comments 0 | with audio podcast

New study links tanning beds to non-melanoma skin cancer

Indoor tanning beds can cause non-melanoma skin cancer – and the risk is greater the earlier one starts tanning, according to a new analysis led by UCSF.

Cancer created Oct 02, 2012 | popularity 5 / 5 (2) | comments 1 | with audio podcast

Drug combination against NRAS-mutant melanoma discovered

A new study published online in Nature Medicine, led by scientists at The University of Texas MD Anderson Cancer Center, describes the discovery of a novel drug combination aimed at a subset of melanoma patients who curren ...

Cancer created Sep 17, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Melanoma: Whole-genome sequencing of 25 tumors confirms role of sun damage, reveals new genetic alterations

Melanoma – the deadliest and most aggressive form of skin cancer – has long been linked to time spent in the sun. Now a team led by scientists from the Broad Institute and Dana-Farber Cancer Institute has sequenced ...

Cancer created May 09, 2012 | popularity 5 / 5 (5) | comments 2 | with audio podcast

Scientists uncover mechanism for melanoma drug resistance

Cancer is tough to kill and has many ways of evading the drugs used by oncologists to try and eliminate it.

Cancer created Mar 06, 2012 | popularity 5 / 5 (4) | comments 0 | with audio podcast

Using patients' own tumor-fighting cells to knock back advanced melanoma

A small, early-phase clinical trial to test the effectiveness of treating patients with advanced melanoma using billions of clones of their own tumor-fighting cells combined with a specific type of chemotherapy has shown ...

Cancer created Mar 05, 2012 | popularity 4.8 / 5 (5) | comments 0 | with audio podcast

Researchers engineer blood stem cells to fight melanoma

Researchers from UCLA's cancer and stem cell centers have demonstrated for the first time that blood stem cells can be engineered to create cancer-killing T-cells that seek out and attack a human melanoma. The researchers ...

Cancer created Nov 28, 2011 | popularity 5 / 5 (4) | comments 1 | with audio podcast


Melanoma i/ˌmɛləˈnoʊmə/ (from Greek μέλας - melas, "dark") is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye (see uveal melanoma). Melanoma can occur in any part of the body that contains melanocytes.

Melanoma is less common than other skin cancers. However, it is much more dangerous and causes the majority (75%) of deaths related to skin cancer. Worldwide, doctors diagnose about 160,000 new cases of melanoma yearly. The diagnosis is more frequent in women than in men and is particularly common among Caucasians living in sunny climates, with high rates of incidence in Australia, New Zealand, North America, Latin America, and northern Europe. According to a WHO report, about 48,000 melanoma related deaths occur worldwide per year.

The treatment includes surgical removal of the tumor, adjuvant treatment, chemo- and immunotherapy, or radiation therapy. The chance of a cure is greatest when the tumor is discovered while it is still small and thin, and can be entirely removed surgically.

This text uses material from Wikipedia and is available under the GNU Free Documentation License.

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