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Immunology news
Oncology & Cancer
A battle of rafts: How molecular dynamics in CAR T cells explain their cancer-killing behavior
A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer.
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Immunology
T cells' capability to fully prevent acute viral infections opens new avenues for vaccine development
Scientists from Duke-NUS Medical School and the Singapore General Hospital have discovered that T cells—white blood cells that can destroy harmful pathogens—can completely prevent viral infection, to an extent previously ...
5 hours ago
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Super-resolution microscopy shows how therapeutic antibodies work against cancer cells
In blood cancers such as chronic lymphocytic leukemia, B cells of the immune system multiply uncontrollably. One form of therapy involves labeling the CD20 protein on the surface of the B cells with customized antibodies. ...
5 hours ago
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Kidney cancer study identifies factors for exceptional response to immunotherapy
Metastatic clear cell renal cell carcinoma (mccRCC), an aggressive type of kidney cancer, has historically presented limited treatment options. Immune checkpoint inhibitors, a form of immunotherapy, can lead to exceptional, ...
Jan 9, 2025
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Researchers identify risk factors for poor prognosis in alopecia areata
Alopecia areata (AA) is a common autoimmune disease that leads to sudden circular hair loss. The clinical course of AA is unpredictable and varies greatly from individual to individual. Numerous studies have shown that AA ...
23 hours ago
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Blood immune cells could hold key to showing disease progression in Parkinson's
A new discovery in blood immune cells has put researchers one step closer to identifying a blood biomarker that would allow doctors to personalize treatments for Parkinson's disease.
Jan 9, 2025
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Targeted centrosome inheritance during CD8⁺ T cell division plays role in memory precursor cell generation: Study
A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8+ T cell division for the generation of memory precursor cells.
Jan 9, 2025
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Study identifies TBK1 as key to overcoming CAR T resistance
Russell W. Jenkins, MD, Ph.D., a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author ...
Jan 9, 2025
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Kidney disease compromises survival of infection-fighting cells, study reveals
Fighting off infections when one has a chronic disease is a common problem, and during the COVID-19 pandemic that scenario often turned out to be dangerous and deadly. A new study led by Stony Brook Medicine demonstrates ...
Jan 8, 2025
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Macrophages, not T cells, may hold key to predicting which melanoma patients are more likely to respond to immunotherapy
An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that engulf pathogens and cancer cells—can be used to predict whether or not a melanoma patient ...
Jan 8, 2025
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Immune-targeted approach helps control tuberculosis in mice
Mice infected with the bacteria that cause tuberculosis (TB) fared better when treated with an experimental compound that modulates immune responses than untreated mice did, according to a study led by Christina Stallings, ...
Jan 7, 2025
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Researchers reveal how psychological stress may aggravate skin allergies
Psychological stress is known to exacerbate skin allergies, but the underlying molecular mechanisms remain poorly understood.
Jan 7, 2025
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Gene therapy could treat chronic hypereosinophilia
A study published in Human Gene Therapy has involved the generation of a human monoclonal antibody (mAb) directed against human eosinophils. The heavy and light chains of that fully human anti-human eosinophil mAb were delivered ...
Jan 7, 2025
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Scientists develop 'suspended animation' technique for blood draws to aid research for underserved populations
Your blood is a delicate mixture. Researchers and clinicians often use blood to learn what's going on inside our bodies, in part because siphoning off a tube of blood is easier and less painful than taking biopsies of an ...
Jan 6, 2025
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Novel screening tech enhances identification of cancer-targeting T cell receptors
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a new screening technology, Aptamer-based T Lymphocyte Activity Screening and ...
Jan 6, 2025
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Bile acids' surprising role in food allergy treatment revealed
Metabolites—small molecules within cells, biofluids, tissues or organisms—play an integral role in various diseases, and studying the many metabolites (metabolomics) can teach us how the body works in ways that help researchers ...
Jan 6, 2025
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Discovery of immune-boosting fibroblasts offers hope for cancer patients
Southampton scientists working to improve survival for cancer patients have identified a key characteristic of the disease that could make treatment more effective.
Jan 6, 2025
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Exploring IL-8⁺ neutrophils and their role in severe alcohol-associated hepatitis
Alcohol-associated hepatitis (AH) is a critical global health issue characterized by acute liver inflammation and an elevated risk of mortality in its severe form (sAH). While the condition has been studied extensively, effective ...
Jan 6, 2025
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Scientists unveil surprising human vs. mouse differences in a major cancer immunotherapy target
Since its discovery in the 1990s, programmed cell death protein 1 (PD-1) has been regarded as a leading target in cancer treatments. A checkpoint receptor that often resides on the surface of immune system cells, the PD-1 ...
Jan 3, 2025
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How a simple amino acid could shape immune response
A study conducted by researchers at the Kennedy Institute of Rheumatology has uncovered a pivotal role of asparagine metabolism in regulating B cell homeostasis and immune response.
Jan 3, 2025
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Novel class of anti-malaria antibodies could lead to next-generation interventions
A novel class of antibodies that binds to a previously untargeted portion of the malaria parasite could lead to new prevention methods, according to a study by researchers at the National Institutes of Health (NIH) published ...
Jan 3, 2025
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FDA approves subcutaneous opdivo qvantig for most solid tumor indications
The U.S. Food and Drug Administration has approved Opdivo Qvantig (nivolumab and hyaluronidase-nvhy) injection for subcutaneous use for most previously approved adult, solid tumor Opdivo (nivolumab) indications.
Jan 3, 2025
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Discovery of CAR-T 'memory cells' could boost cancer therapy
Researchers at the University of Colorado Anschutz Medical Campus have discovered that some CAR-T cells engineered to fight cancer and other conditions carry the memory of past encounters with bacteria, viruses and other ...
Jan 2, 2025
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Blood test can predict how long vaccine immunity will last, study shows
When children receive their second measles-mumps-rubella vaccine, around the time they start kindergarten, they gain protection against all three viruses for all or most of their lives. Yet the effectiveness of an influenza ...
Jan 2, 2025
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Microglia digest large Alzheimer's plaques by spitting enzymes at them, preclinical study finds
Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing digestive enzymes into ...
Jan 2, 2025
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