Revealed: Secret of HIV's natural born killers

Scientists on Sunday said they had found a key piece in the puzzle as to why a tiny minority of individuals infected with HIV have a natural ability to fight off the deadly AIDS virus.

In a study they said holds promise for an , researchers from four countries reported the secret lies not in the number of infection-killing cells a person has, but in how well they work.

Only about one person in 300 has the ability to control the (HIV) without drugs, using a strain of "killer" cells called cytotoxic T lymphocyte (CTL) cells, previous research has found.

Taking that discovery further, scientists from the United States, Canada, Japan and Germany reported that the strain has molecules called receptors that are better able to identify HIV-infected for attack.

Until now, it was well known that people with HIV "have tonnes of these ," Bruce Walker, an infectious diseases expert at the Ragon Institute in Massachusetts, told AFP.

"We have been scratching our heads since then, asking how, with so many killer cells around, people are getting AIDS. It turns out there is a special quality that makes them (some cells) better at killing."

The study looked at 10 infected people, of whom five took to keep HIV under control while five were so-called elite controllers who remained naturally healthy.

HIV kills a type of white blood cell called CD4, leaving people with AIDS wide open to other, opportunistic and potentially .

"What we found was that the way the killer cells are able to see infected cells and engage them was different," said Walker.

"It is not just that you need a killer cell, what you need is a killer cell with a (T cell) receptor that is particularly good at recognising the infected cell. This gives us a way to understand what it is that makes a really good killer cell."

Walker said attempts at creating vaccines had so far failed because the T they generated were not the efficient type.

But while the research has showed scientists how to find and measure the good cells, they still do not yet know how to generate them.

"The next step is to determine what it is about those receptors that is endowing them with that ability," said Walker.

"HIV has revealed another one of its secrets and that is how the body is able to effectively control the virus in certain individuals.

"Each secret that HIV reveals is putting us in a better position to ultimately make a vaccine to control the virus."


Explore further

Researchers genetically engineer immune cells into potent weapons for battling HIV

More information: Nature Immunology, DOI: 10.1038/ni.2342
Journal information: Nature Immunology

(c) 2012 AFP

Citation: Revealed: Secret of HIV's natural born killers (2012, June 10) retrieved 24 October 2020 from https://medicalxpress.com/news/2012-06-revealed-secret-hiv-natural-born.html
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