Researchers identify a metabolite as a biomarker of diabetes risk

Type 2 diabetes (T2D) is the most common form of diabetes and is associated with many complications. T2D is preventable through weight control and exercise; however, many individuals are unaware that they are at risk and do not change their lifestyle in time to avoid disease.

In this issue of the Journal of Clinical Investigation, Robert Gerszten and colleagues at Massachusetts General Hospital identify the metabolite 2-aminoadipic acid (2-AAA) as a biomarker for T2D diabetes risk. Individuals with increased levels of 2-AAA had a much greater risk of developing diabetes than individuals with lower 2-AAA levels.

The authors found that this metabolite was present in at-risk individuals up to 12 years before to T2D onset. Additionally, addition of 2-AAA to isolated pancreatic cells from both mice and humans enhanced .

This study provides a biomarker of T2D risk that is a potential for the regulation of glucose homeostasis.


Explore further

Genetic predisposition to diabetes ups risk of CVD

More information: 2-Aminoadipic acid is a biomarker for diabetes risk, J Clin Invest. DOI: 10.1172/JCI64801
Citation: Researchers identify a metabolite as a biomarker of diabetes risk (2013, September 16) retrieved 1 April 2020 from https://medicalxpress.com/news/2013-09-metabolite-biomarker-diabetes.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments