New imaging technique spots prostate tumours starved of oxygen

A new imaging technique uncovers oxygen levels in prostate tumours and could lead to a non-invasive way to determine which tumours are more difficult to treat, according to a Cancer Research UK-funded study published in Theranostics.

Scientists at the University of Cambridge created a new technique with an imaging device using a combination of light and sound to check the in prostate tumours in mice.

They gave mice a short burst of pure to breathe, and monitored how quickly and efficiently the extra oxygen reached different tumour areas through the blood supply.

Using the , the researchers were able to image the stronger response to oxygen by tumours with better blood vessels, which could give vital information on the quality of vessels.

This could help doctors find patients with harder to treat prostate cancers. Cancer cells supplied by poor quality blood vessels and low oxygen levels – called hypoxic conditions - are more resistant to drugs and radiotherapy.

Not only are cells in hardier and better at adapting to harsh conditions, making them more aggressive, but poor blood vessels also reduce the number of treatments like chemotherapy that can penetrate into the heart of the tumour.

Dr Sarah Bohndiek, scientist at the Cancer Research UK Cambridge Institute, said: "Our new imaging technique gives us a clearer picture of the heart of prostate than we have ever had before.

"The tortuous nature of blood vessels can leave tumours starved of oxygen – making the cancer resistant to radiotherapy and chemotherapy and very difficult to treat. If we can translate this technology to the clinic, we could provide a non-invasive way to stratify men for treatment and monitor the effect of different therapies."

Every year, about 46,500 men are diagnosed with prostate cancer and around 11,000 men die from the disease.

Prof Karen Vousden, Cancer Research UK's chief scientist, said: "This new technique compliments existing MRI and PET scans by helping us learn more about within the tumour, which we haven't been able to look at before in this way.

"It's important that we develop better techniques to understand a patient's individual tumour. This new tool gives insight into the tumour environment and could help separate the less aggressive forms of from the more difficult to treat.

More information: Michal R Tomaszewski et al. Oxygen Enhanced Optoacoustic Tomography (OE-OT) Reveals Vascular Dynamics in Murine Models of Prostate Cancer, Theranostics (2017). DOI: 10.7150/thno.19841

Provided by Cancer Research UK
Citation: New imaging technique spots prostate tumours starved of oxygen (2017, August 24) retrieved 18 April 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers map brain tumour cells' adaptation to oxygen deprivation


Feedback to editors