Strain of common cold virus could revolutionize treatment of bladder cancer

cancer
Killer T cells surround a cancer cell. Credit: NIH

A strain of the common cold virus has been found to potentially target, infect and destroy cancer cells in patients with bladder cancer, a new study in the medical journal Clinical Cancer Research reports. No trace of the cancer was found in one patient following treatment with the virus.

Researchers from the University of Surrey and Royal Surrey County Hospital investigated the safety and tolerability of exposure to the oncolytic ('-killing') virus coxsackievirus (CVA21), a naturally occurring strain of the common cold, in fifteen patients with non-muscle invasive (NMIBC). NMIBC is found in the tissue of the inner surface of the bladder and is the tenth most common cancer in the UK with approximately 10,000 people each year diagnosed with the illness.

Current treatments for this cancer are problematic. Transurethral resection, an invasive procedure that removes all visible lesions, has a high tumour recurrence rate ranging from 50 per cent to 70 per cent as well as a high tumour progression rate between 10 per cent and 20 per cent over a period of two to five years. Another common course of , immunotherapy with Bacille Calmette-Guerin, a live bacterium used to treat bladder cancer, has been found to have in one third of NMIBC patients while one third do not respond to the treatment at all.

During this pioneering study fifteen NMIBC patients, one week prior to pre scheduled surgery to remove their tumours, received CVA21 via a catheter in the bladder. Examination of tissue samples post-surgery discovered that the virus was highly selective, targeting only in the organ and leaving all other cells intact. The virus was found to have infected cancerous cells and replicated itself causing the cells to rupture and die. Urine samples taken from patients on alternate days detected 'shedding' from the virus indicating that once virally infected had died, the newly replicated virus continued to attack more cancerous cells in the organ.

Typically tumours in the bladder do not have , preventing a patient's own immune system from eliminating the cancer as it grows. Evidence suggests treatment with CVA21 inflames the tumour causing immune cells to rush into the cancer environment, targeting and killing the cancer cells. These tumours devoid of immune cells are known as 'cold' areas immunologically; however, treatment with the virus causes inflammation and immune cell stimulation to create 'immunological 'heat'. 'Hot' tumours in this way are more likely to be rejected by the immune system.

Following treatment with the virus cell death was identified in the majority of the patients' tumours. In one patient no trace of the cancer was found during surgery.

Hardev Pandha, Principal Investigator of the study and Professor of Medical Oncology at the University of Surrey, said: "Non-muscle is a highly prevalent illness that requires an intrusive and often lengthy treatment plan. Current treatment is ineffective and toxic in a proportion of patients and there is an urgent need for new therapies.

"Coxsackievirus could help revolutionise treatment for this type of cancer. Reduction of tumour burden and increased cancer cell death was observed in all patients and removed all trace of the disease in one patient following just one week of treatment, showing its potential effectiveness. Notably, no significant side effects were observed in any patient."

Dr. Nicola Annels, Research Fellow at the University of Surrey, said: "Traditionally viruses have been associated with illness however in the right situation they can improve our overall health and wellbeing by destroying cancerous cells. Oncolytic viruses such as the coxsackievirus could transform the way we treat cancer and could signal a move away from more established treatments such as chemotherapy."


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Journal information: Clinical Cancer Research

Citation: Strain of common cold virus could revolutionize treatment of bladder cancer (2019, July 5) retrieved 15 October 2019 from https://medicalxpress.com/news/2019-07-strain-common-cold-virus-revolutionize.html
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Jul 06, 2019
The definition of a common cold virus is interesting,as enterovirus infections are the commonest infection after the common cold.Common colds are infections of many different types of rhinoviruses,on which research in the uk to find a vaccine was abanded.Enteroviruses are of 4 main types;polio,cocksackieA(CVA),cocksackieB
(CVB)& Entero-Cytotoxic Human Orphan Viruses(ECHO).Polio virus cause polio,the other 3 cause Myalgic Encephalomyelitis.
TBC

Jul 06, 2019
M.E. is based on peer reviewed scientific papers going back to 1907,and consequently the World Health Organisation
inserted it into the International Classification of Diseases ICD G93.3 Neuroligical diseases.Cocksackie viruses can cause myocarditis to lethal effect.
The battle between science and geo-political economy is in this issue.Global insurance companies were monetarily panicked by the rise in infection causing ME to be the main cause of long term absence from school.They are one of the largest global lobbying forces and spent large amounts of resources gaining the support of the establishment/powers that be/so-called elites obfuscating the science
and using Social Control & Social Engineering to influence the public.The science totally lost,like global heating.

Jul 15, 2019


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