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Common arthritis pill repurposed to boost hair regrowth in alopecia patients

Upadacitinib is a medication widely used for the treatment of rheumatoid arthritis that works by inhibiting Janus kinase (JAK) enzymes, which are involved in signaling pathways that regulate immune responses. Now, scientists ...

Experimental pill targets nerve pain pathway, cutting opioid use after abdominal surgery

Opioids can be highly effective at relieving moderate to severe pain, whether it comes from surgery, an injury or conditions such as cancer. They work by activating opioid receptors in the brain and body, which block pain ...

Medical research news

Laser therapy offers weapon against deadly brain tumors

For patients facing a diagnosis of glioblastoma—one of the most aggressive and devastating forms of brain cancer—the standard path forward has long meant invasive open-skull surgery and a daunting prognosis.

Flexible brain circuits can switch between different tasks

As we move through everyday life, our brains engage in a huge variety of cognitive tasks. For example, during a grocery run, we might have to recall the items for a recipe, remember where the clerk said the flour was located ...

Rare gene variants may multiply Alzheimer's disease risk

Alzheimer's disease is the most common form of dementia worldwide, and its development is influenced by a combination of genetic and environmental factors. In recent years, the PLCG2 gene and its encoded enzyme, PLCγ2, have ...

Video games built for prevention can reduce teen depression

Few parents or teachers are likely to suggest that teenagers could benefit from playing more video games. But a new study suggests that a growing class of educational games may be a highly effective tool for treating and ...

ULTRA maps glioma margins in 3D within 30 minutes

One of the major challenges in glioma surgery is that tumor boundaries are often difficult to define. Diffuse gliomas can infiltrate surrounding brain tissue beyond what surgeons can see directly or what conventional imaging ...

Genetic variants shed light on kidney transplant rejection

Immunosuppressive medications help prevent organ rejection following transplantation, yet some patients still experience rejection despite receiving adequate treatment. New research from Yale, published in the Journal of ...

Unexpected brain mechanism challenges assumptions about GLP-1s

For decades, obesity medications produced only modest weight loss. But in recent years, Ozempic and related GLP-1 therapies have transformed the field, enabling sustained weight loss of 10% to 15% or more. Despite their success, ...

Simple blood test on a chip could help diagnose lung cancer

Researchers at Tel Aviv University have developed a new method for diagnosing lung cancer: a simple, fast, low-cost blood test that does not require DNA sequencing. The method identifies a chemical fingerprint of cancer cells ...

AI framework decodes how brain regions talk to one another

For decades, neuroscientists have been able to record which parts of the brain show increased electrical activity during a behavior, such as when we form a memory or make a decision. But scientists haven't been able to determine ...

Why a doctor saying 'it's normal' can backfire

A new study from the University of California San Diego Rady School of Management suggests that when physicians try to reassure patients by saying their symptoms are "normal," patients may infer that treatment isn't necessary—and ...