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Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin

Research published in Frontiers of Medicine evaluates the human epidermal growth factor receptor 2 (HER2) status in extramammary Paget disease (EMPD) and explores the therapeutic potential of disitamab vedotin (DV), a novel ...

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Investigational mpox mRNA vaccine more effectively reduces disease severity in primates compared to available vaccines

The most frequently used mpox vaccine provides partial immunity to the disease but isn't always able to prevent severe symptoms or disease transmission. A new vaccine candidate from Moderna, mRNA-1769, more effectively limits ...

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Newly discovered gene may influence longevity in humans

Sleep, fasting, exercise, green porridge, black coffee, a healthy social life—there is an abundance of advice out there on how to live a good, long life. Researchers are working hard to determine why some people live longer ...

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New approach moves cell therapy closer to treating many disorders

A new approach to manufacturing cells that secrete and deliver therapies to specific parts of the body has taken a big step toward one day repairing joints and damage after heart attacks, countering transplant rejection and ...

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Blood stem cell research could transform bone marrow transplants

Melbourne researchers have made a world first breakthrough in creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia ...

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Ultrasound device shows promise for treating chronic pain

Pain is a necessary biological signal, but a variety of conditions can cause those signals to go awry. For people with chronic pain, the root is often faulty signals emerging deep within the brain, giving false alarms about ...

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Review highlights advances in kidney cancer research and care

New insights into the biology of kidney cancer, including those informed by scientific discoveries that earned a Nobel Prize, have led to advances in treatment and increased survival rates, according to a review by UNC Lineberger ...

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Formula milk trials are not reliable, warn experts

Formula milk trials have a high risk of bias, authors almost always report favorable conclusions, transparency is lacking, and findings are selectively reported, finds a review of evidence from recently published trials in ...

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Mapping the effects of genetic variation, one letter at a time

In the two decades since the human genome was first sequenced, scientists have learned much about how the genome is organized and how widely it varies between people around the globe. A better view of how that genetic variation ...

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Nerve repair, with help from stem cells

A new approach to repairing peripheral nerves marries the regenerating power of gingiva-derived mesenchymal stem cells with a biological scaffold to enable the functional recovery of nerves following a facial injury, according ...

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Stem cells and their role in lung transplant rejection

A lung transplant can mean the difference between life and death for people with diseases such as pulmonary fibrosis, chronic obstructive pulmonary disease (COPD) and even severe COVID-19. Yet, recipients of donor lungs must ...

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Toxic fatty acids to blame for brain cell death after injury

Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows. This phenomenon is likely the driving factor behind most, if not all, diseases ...

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Tiny bubbles can be future treatment for inflammation

Scientists hope that tiny sacs of material excreted by cells—so-called extracellular vesicles—can be used to deliver drugs inside the body. Researchers at Karolinska Institutet now show that these nano-bubbles can transport ...

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Biomarkers could spell the end of anorexia nervosa

Researchers from the Swinburne Anorexia Nervosa (SWAN) Research Group have discovered what is believed to be the first biomarker for anorexia nervosa. Biomarkers are typically used in the detection and treatment of physical ...

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Defining a healthy microbiome

In a new study, Bärbel Stecher and her team from LMU have shown that, depending on the composition of the microbiome, E. coli bacteria can prevent infections by Salmonella strains.

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Cause found for higher sex-specific risk of mortality

A remarkable number of life-threatening diseases manifest more severely in males than in females. One current example is COVID-19 caused by SARS CoV-2. Another example is the significantly higher risk of severe cancer progression ...