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Immunology news
Immunology
Novel mechanism for targeting bone marrow adipocytes to prevent bone loss
Bone marrow adipocytes (BMAds) are situated within the bone microenvironment, in close proximity to bone cells, vascular structures, and hematopoietic tissues. The shift of bone marrow stromal/stem cells (BMSCs) lineage towards ...
12 hours ago
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Oncology & Cancer
Breakthrough research makes cancer-fighting viral agent more effective
When a cancer cell doesn't respond to traditional therapies, doctors may turn to a sort of viral biological warfare, by deploying "troops" in the form of viral agents that are specifically engineered to target and eliminate ...
12 hours ago
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Study suggests changing the gut microbiome improves health outcomes for newly-diagnosed metastatic kidney cancer
Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called ...
17 hours ago
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Chemical conjugation mitigates immunotoxicity of chemotherapy of lipid nanoparticles
While chemotherapy can stimulate antitumor immunity, it may also impair immune cell function and induce lymphodepletion, reducing the effectiveness of subsequent immunotherapy. Thus, nanoparticle-based drug delivery systems ...
17 hours ago
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Vaccination may reduce memory loss from COVID-19 infections
Since the outset of the COVID-19 pandemic, 10 to 30% of the general population has experienced some form of virus-induced cognitive impairment, including trouble concentrating, brain fog or memory loss. This led a team of ...
Jun 27, 2024
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Understanding the mechanism behind melanoma resistance to treatment
In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance. These findings ...
Jun 27, 2024
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Two studies show mixed progress against eosinophilic esophagitis
Despite high hopes, a drug that wipes out the namesake cell type associated with the disease eosinophilic esophagitis (EoE) doesn't make patients feel better and doesn't reverse tissue damage in their throats.
Jun 27, 2024
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Switching decisions: Interleukin-12 influences B cell immune response
B cells are known to generate antibodies through two different responses—an "emergency response" and an "everything is okay, let's prepare for the future response," says Mark Shlomchik, UPMC Professor and Distinguished ...
Jun 27, 2024
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Researchers pioneer production of CAR T-cells using high-density microfluidic bioreactor
Researchers have developed a novel method capable of producing clinical doses of viable autologous chimeric antigen receptor (CAR) T-cells in a ultra-small automated closed-system microfluidic chip, roughly the size of a ...
Jun 27, 2024
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Master autoimmune regulator gets by with a little help from its friends
The protein Foxp3 is vital to the function of immune cells called regulatory T cells, which control immune system activation. Despite its importance, how Foxp3 regulates the immune system using environmental cues has remained ...
Jun 27, 2024
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A new method to study immune cells offers hope for finding new disease treatments
Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair. Understanding how these cells are activated in different scenarios is important for developing new medical treatments. ...
Jun 26, 2024
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Promising pathway discovered to treat rare childhood brain disease
Aicardi-Goutieres syndrome is a rare disease that can trigger dementia in children. Associate Professor Markus Hofer and colleagues in the U.K. are focusing on treatments in the blood vessels in the brain to combat AGS.
Jun 26, 2024
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Fatigue with rheumatoid arthritis tied to disease activity, education level
The Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional Questionnaire (BRAF-MDQ) and Brief Fatigue Inventory (BFI-C) scores show consistency in assessing fatigue with rheumatoid arthritis (RA), according to a study published ...
Jun 26, 2024
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Starving cancer cells to enhance DNA damage and immunotherapy response
A new research perspective titled "Starving cancer cells to enhance DNA damage and immunotherapy response" has been published in Oncotarget.
Jun 26, 2024
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Researchers develop hybrid antibody with improved immune activation
Antibodies can be likened to keys, with antigens as the corresponding locks. Each antibody is uniquely shaped to fit a specific antigen, much like a key fits its particular lock. The precise ability to bind to disease-causing ...
Jun 25, 2024
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Researchers design novel 3D hydrogel culture to study TB infection and treatment
Researchers from the Department of Bioengineering (BE), Indian Institute of Science (IISc), have designed a novel 3D hydrogel culture system that mimics the mammalian lung environment. It provides a powerful platform to track ...
Jun 25, 2024
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New study demonstrates the efficacy of a promising celiac disease drug at the molecular level
A recent study led by researchers at Tampere University investigated whether a transglutaminase 2 inhibitor has potential as a drug to treat celiac disease. Previous tissue studies have shown that the ZED1227 transglutaminase ...
Jun 24, 2024
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Aerobic exercise tied to improved clinical asthma outcomes
Moderate- and vigorous-intensity aerobic exercise training are associated with improvements in clinical asthma outcomes, according to a study published in The Journal of Allergy and Clinical Immunology: in Practice.
Jun 24, 2024
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Growth factors linked to stem cell aging in bone marrow study
Our bone marrow—the fatty, jelly-like substance inside our bones—is an unseen powerhouse quietly producing 500 billion new blood cells every day. That process is driven by hematopoietic stem cells that generate all of ...
Jun 22, 2024
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Discovery holds promise to restore function in people with paralysis and neurological diseases
In a new study, neuroscience researchers at The Ohio State University have discovered a special type of human white blood cell that has the potential to regrow nerve fibers.
Jun 21, 2024
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