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Immunology news
Immunology
Nanobodies help decode the central mechanism of inflammation
The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine ...
2 hours ago
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Metabolic reprogramming of T cells may enhance checkpoint inhibitor therapy
Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study led by researchers at Weill Cornell ...
5 hours ago
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Unexpected immune response may hold key to long-term cancer remission
Results from a preclinical study in mice led by EPFL, and a collaborative clinical study in patients show that the type 2 immune response—associated with parasitic infection and thought to play a negative role in cancer ...
7 hours ago
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Scientists develop CAR-T cells to target glioblastoma while sparing healthy tissue
Scientists at UNIGE and HUG have developed CAR-T cells capable of targeting malignant gliomas while preserving healthy tissue.
8 hours ago
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Novel antibodies against Klebsiella pneumoniae identified
Research at UMC Utrecht has identified 29 novel antibodies against the bacterium Klebsiella pneumoniae, an important cause of drug-resistant infections. Using genetic and functional approaches, the researchers also managed ...
8 hours ago
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Researchers discover treatment for major cause of recurrent pregnancy loss
Among women who experience recurrent pregnancy loss, around 20% test positive for a specific antibody that targets the mother's own body. A Kobe University-led research team has now found a treatment that drastically increases ...
18 hours ago
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Newly identified 'compound B' holds promise as better immune booster against cancer, chronic diseases
A team of University of Alberta researchers has created a molecular compound that activates the immune system and shows promise for becoming an effective and versatile treatment for cancer and chronic infections.
5 hours ago
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Tumor-specific antibodies able to detect melanoma in its earliest stages, new study shows
Innovative research has unveiled promising advancements in melanoma detection, which could significantly enhance diagnosis and prognosis by identifying the disease at its earliest, most treatable stages.
Sep 25, 2024
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Combination treatment improves response to immunotherapy for lung cancer, mouse study shows
Researchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive ...
Sep 25, 2024
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An eye on viruses in wastewater: Q&A with virologist
Virologist Rúbens Alves, Ph.D., came to La Jolla Institute for Immunology (LJI) to contribute to life-saving vaccine research. As a member of LJI's Shresta Lab, Alves studied how T cells fight viruses such as SARS-CoV-2 ...
Sep 25, 2024
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Immune cells caught between worlds: Researchers explore how innate-like T cells mature
Our immune system spans two worlds—innate and adaptive. Innate immune cells are like troops at the gate ready to hold off invaders and raise the body's alarms. Adaptive immune cells are specialists that take longer to respond ...
Sep 24, 2024
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Researchers discover new role of immune cells in eye health
The eye is an immune-privileged tissue because of the need to keep blood vessels away from the central pathway of light and to restrict entry of inflammatory cells that could cause damage. This has prompted questions about ...
Sep 24, 2024
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Oncologist explains new treatment for advanced melanoma called tumor-infiltrating lymphocyte therapy
Melanoma is a dangerous form of skin cancer that has the potential to spread to other parts of the body.
Sep 24, 2024
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Researchers 'turbocharge' vaccine delivery by jolting 'bystander' immune cells into action in animal models
Monash University researchers have developed a new technique to boost the effectiveness of both traditional and mRNA-based vaccines in animal models.
Sep 23, 2024
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Study sheds new light on immune dysfunction in children with severe infections and inflammatory diseases
A new study led by King's College London, Imperial College London and the University of Edinburgh, has characterized the similarities and differences between immune cell profiles in children with different infections and ...
Sep 23, 2024
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B-cells hold promise for treating glioblastoma
Harnessing the body's B-cells to fight tumors may be a promising treatment for glioblastoma, according to a Northwestern Medicine study recently published in the Journal of Clinical Investigation.
Sep 23, 2024
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Systemic sclerosis research finds protein TLR8 influences the production of disease-related cytokines
Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such as the lungs and heart. It is considered a rare disease, and little is yet known about its development ...
Sep 23, 2024
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Fever drives enhanced activity and mitochondrial damage in a subset of T cells, study finds
Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also—in a particular subset of T cells—cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center ...
Sep 20, 2024
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Researchers discover immune response to dengue can predict risk of severe reinfections
As the dengue virus continues to be a significant global health concern, an international research team led by Duke-NUS Medical School has identified a critical link between the body's initial immune response and its defense ...
Sep 20, 2024
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Identifying sex-based differences in immune responses against tumors
Researchers at Saint Louis University School of Medicine investigated differences in T-cell responses between male and female patients with lung cancer that may help direct future treatments. T-cell responses are part of ...
Sep 20, 2024
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Study: Inflammatory cells in tumor microenvironment transform prostate cancer cells into treatment-resistant cells
Treatment-resistant cells are a challenge related to prostate cancer and many other cancers, which arises as the disease progresses. However, these resistance mechanisms are not yet fully understood.
Sep 20, 2024
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Immune cells linked to blood vessel damage and neurodegeneration
A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage.
Sep 19, 2024
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Low oxygen levels in tumors could enhance some of the body's immune responses against cancer
In the complex landscape of cancer, tumors create their own microenvironment, often marked by low oxygen levels, a condition known as hypoxia. Hypoxia arises as tumors grow rapidly, outpacing their blood supply due to the ...
Sep 19, 2024
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New combination treatment brings hope to patients with advanced bladder cancer
Findings from the international FORT-2 clinical trial showed that a combination treatment including immunotherapy is safe and tolerable in patients with locally advanced or metastatic bladder cancer. The results, published ...
Sep 19, 2024
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