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Immunology news
Immunology
H5N8 avian influenza vaccine produces robust immune responses, new study finds
Finland was the first country to offer the zoonotic avian influenza A(H5N8) vaccine manufactured by Seqirus to at-risk occupational groups following the extensive clade 2.3.4.4b A(H5N1) outbreak affecting wild birds and fur ...
18 hours ago
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Oncology & Cancer
Antibody halts triple-negative breast cancer in preclinical models
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant forms of breast cancer. It grows quickly, spreads early and lacks the hormone receptors that make other breast cancers treatable with ...
Dec 4, 2025
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New approach makes common breast cancer type responsive to immunotherapy
A study led by researchers at the Hospital del Mar Research Institute advances one of the most significant milestones in breast cancer treatment, making immunotherapy effective against the most common tumor type, estrogen ...
Dec 4, 2025
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Modified herpes virus helps destroy glioblastoma in preclinical models
Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells. A single dose of the modified virus increased T-cell, natural killer cell, and ...
Dec 4, 2025
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Microglia replacement paves way for neurodegenerative disease therapies, moving from mice to humans in just 5 years
Tiny immune cells called microglia protect the central nervous system (CNS) in a multitude of ways: They provide innate immunity, shape neurodevelopment, maintain homeostasis and modulate neurological disorders. That functionality ...
Dec 4, 2025
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To treat long COVID, we must learn from historical chronic illnesses, medical researchers say
In a paper published in Trends in Immunology, scientists and doctors highlight the importance of studying long COVID in the context of other post-acute infection syndromes or chronic illnesses. By analyzing historical accounts ...
Dec 4, 2025
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T cells found in tonsils differ in key ways from those in blood
T cells, also known as lymphocytes, are a type of white blood cell that play an important role in the body's immune response. Historically, blood samples have been used to monitor how T cells respond to a virus, vaccine or ...
Dec 4, 2025
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Recent trial reveals promising therapy for aggressive brain cancer
Huntsman Cancer Institute at the University of Utah (the U) participated in a clinical trial that found that a new combination treatment plan helped people with recurring grade 3 astrocytoma, an aggressive form of brain cancer, ...
Dec 4, 2025
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Why stress can make your hair fall out: A two-part reaction
It's well known that stress can trigger hair loss. A new paper explores how this happens and how our response to stress can have long-term consequences for our scalps, research that may eventually yield insights into autoimmune ...
Dec 3, 2025
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NeuMap: A pioneering map of neutrophils that redefines their role in health, infection and inflammation
Neutrophils are the most abundant immune cells in the body and the first to respond to infection or tissue damage. Yet despite their importance, until now very little was known about how they truly function, how they change ...
Dec 3, 2025
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Breast cancer remodels lymphatic vessels to accelerate its spread, research reveals
Breast cancer is able to modify the lymphatic vessels through which it travels to the draining lymph nodes. From there, it can then spread to other parts of the body. A new finding by Finnish researchers may help develop ...
Dec 3, 2025
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Newly defined benign soft tissue tumor with bony shell may mimic malignancy
It's not often that a pathologist gets to make a diagnosis that works for the patient by preventing treatment from occurring. But thanks to a Johns Hopkins Medicine doctor and his newly reported definition and classification ...
Dec 3, 2025
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FDA approves Imfinzi for early gastric and gastroesophageal cancers
The U.S. Food and Drug Administration has approved Imfinzi (durvalumab) in combination with standard-of-care FLOT chemotherapy (fluorouracil, leucovorin, oxaliplatin, and docetaxel) for treating adult patients with resectable, ...
Dec 3, 2025
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FDA approves updated label for Unloxcyt
The U.S. Food and Drug Administration has approved an updated label for Unloxcyt (cosibelimab-ipdl) for the treatment of adults with metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC) who are not candidates ...
Dec 3, 2025
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FDA approves Padcev for muscle-invasive bladder cancer
The U.S. Food and Drug Administration has approved Pfizer's Padcev (enfortumab vedotin-ejfv), a Nectin-4 directed antibody-drug conjugate, as a perioperative neoadjuvant treatment and postcystectomy adjuvant treatment for ...
Dec 3, 2025
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Cancer-fighting bacterial product 'cocktails' may offer personalized treatment
Bacteria may be the next frontier in cancer treatment, according to a team led by researchers at Penn State that devised a new approach of creating bacteria-derived mixtures—or cocktails—to help fight bladder cancer. ...
Dec 2, 2025
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Blocking Claudin-4 protein may help immune system fight aggressive ovarian cancer
Scientists at The University of Texas at El Paso have found a promising new target in the fight against high-grade serous carcinoma, an aggressive form of ovarian cancer. Less than 50% of women survive five years after diagnosis, ...
Dec 2, 2025
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Study compares immune responses from three major COVID-19 vaccine types
A recent study has provided the first side-by-side comparison of how three major COVID-19 vaccine types differ in triggering immune responses and sustaining protection, according to an analysis published in JCI Insight.
Dec 2, 2025
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Why some people with HIV achieve remission after antibody treatment
Researchers led by a team from Mass General Brigham and the Ragon Institute have discovered why some people living with HIV who are given a treatment called broadly neutralizing anti-HIV antibodies (bNAbs) can safely stop ...
Dec 1, 2025
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Long-term HIV control: Combination therapy points way to a possible cure
A new study from UC San Francisco shows it may be possible to control HIV without long-term antiviral treatment—an advance that points the way toward a possible cure for a disease that affects 40 million people around the ...
Dec 1, 2025
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Inflammation and metabolic stress combine to drive a new cell death pathway—mitoxyperilysis
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study from St. Jude Children's Research Hospital, published in Cell, found that this combination ...
Dec 1, 2025
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A molecule opens a breach in HIV, providing access to its reservoirs
An international team led by two Université de Montréal researchers has unveiled how a molecule capable of opening the "shell" of HIV improves the elimination of infected cells.
Dec 1, 2025
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Unexpected pathway for IgA antibody production may help improve vaccines
Scientists led by Stephanie Eisenbarth, MD, Ph.D., the Roy and Elaine Patterson Professor of Medicine and director of the Center for Human Immunobiology, have discovered how critical IgA antibodies are produced through unexpected ...
Dec 1, 2025
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Study investigates treatment safety in cases of late HIV diagnosis
About 40 million people worldwide are living with HIV infection. In the United Kingdom, there are approximately 100,000 people affected. If the infection is not treated, the body will eventually be unable to defend itself ...
Dec 1, 2025
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Lack of dietary iron may impair immune cells' ability to fight influenza
New research published in The Journal of Immunology suggests that a lack of dietary iron can negatively affect the ability of immune cells to respond to viral infection in the lungs. In mice with dietary iron deficiency and ...
Dec 1, 2025
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