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Self-amplifying mRNA vaccines appear safe in lab and animal tests

mRNA vaccines contain instruction codes for making parts of pathogenic viruses. Can so-called self-amplifying types of such vaccines form unwanted and dangerous connections with other viruses? Yes, say Wageningen virologists ...

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How a bacterium supports healing of chronic diabetic wounds

There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain bacterium, Alcaligenes faecalis (A. faecalis), ...

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New protein discovery may influence future cancer treatment

Researchers from the University of Otago, Christchurch, have spearheaded the discovery of a protein function which has the potential to guide the development of novel cancer treatment options and improve the diagnosis of ...

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Study debunks link between moderate drinking and longer life

Probably everyone has heard the conventional wisdom that a glass of wine a day is good for you—or you've heard some variation of it. The problem is that it's based on flawed scientific research, according to a new report ...

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Guideline on management of central airway obstruction released

The American College of Chest Physicians (CHEST) recently released a new clinical guideline on central airway obstruction (CAO). Published in the journal CHEST, the guideline contains 12 evidence-based recommendations to ...

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Cure for male pattern baldness given boost by sugar discovery

The key to curing male pattern baldness—a condition that affects up to 50% of men worldwide—could lie in a sugar that naturally occurs in the human body, according to scientists at the University of Sheffield.

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Peptide cocktails show promise in combating antibiotic resistance

Antibiotics are essential tools in modern medicine, regularly used to treat bacterial infections and prevent infections during surgery. However, the widespread use of antibiotics has led to many bacteria developing resistance, ...

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What lobsters can teach us about immortality

No one likes the thought of getting old, but it seems to be an inevitable part of life. Most species grow, develop and repair damage to their bodies until a certain point in adulthood. After this, the body becomes less capable ...

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When macrophage digestion goes wrong

The exchange of gases between the air we breathe and our blood takes place via alveoli—tiny air sacs in our lungs. For this process to run smoothly, the epithelial cells of the alveoli produce a substance called "surfactant" ...

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Studying fruit flies to better understand depression

Human beings and fruit flies have very little in common—at first sight. However, by studying these flies, it is in fact possible to find out more about human nature, particularly when it comes to depressive disorders.

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Dozens of gut bacteria associated with multiple sclerosis

An international research consortium led by UC San Francisco scientists has shown significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, as well as between MS ...

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New mechanism extends life of immune system

A new mechanism that slows down and may even prevent the natural aging of immune cells—one of the nine hallmarks of aging—has been identified by an international team led by UCL scientists.

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In small study, CAR-T therapy pushes lupus into remission

While there's no cure for lupus and treatments don't work for many of the 1.5 million people who live with the disease in the United States, a new study shows a cancer therapy may kick hard-to-treat lupus into remission.

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Immunotherapy reduces lung and liver fibrosis in mice

Chronic diseases often lead to fibrosis, a condition in which organ tissue suffers from excessive scarring. Researchers at the University of Zurich have now developed an immunotherapy that specifically targets the cause—activated ...

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What clinical trials can teach us

For decades, researchers at the University of Michigan Rogel Cancer Center have been searching for ways to fundamentally change the approach to treating laryngeal cancer and underlying assumptions to improve clinical care ...